Q5HZL5

PR
Gene name
b3gnt5-a
Protein name
Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase A
Names
Lactotriaosylceramide synthase A, Lc(3)Cer synthase A, Lc3 synthase A, UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5A, BGnT-5A, Beta-1,3-Gn-T5A, Beta-1,3-N-acetylglucosaminyltransferase 5A, Beta3Gn-T5A
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:496364
EC number
2.4.1.206: Hexosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

108-185 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5HZL5

Entry ID Method Resolution Chain Position Source
AF-Q5HZL5-F1 Predicted AlphaFoldDB

No variants for Q5HZL5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5HZL5

No associated diseases with Q5HZL5

No regional properties for Q5HZL5

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q5HZL5

Functions

Description
EC Number 2.4.1.206 Hexosyltransferases
Subcellular Localization
  • Golgi apparatus membrane ; Single-pass type II membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name Definition
beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide = UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide.
lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity Catalysis of the reaction: cytolipin-H + UDP-N-acetyl-D-glucosamine = N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide + UDP.

1 GO annotations of biological process

Name Definition
protein glycosylation A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLISARRLRR CQFLQLLASC FVLSLMALLV QEDNSLISHV KSYSYRYLIN SYDFVNVSLS
70 80 90 100 110 120
IPRDRLDGAA SYRYLLNNRH ICLNEDVLLL LFVKTAPENR RRRDAIRNTW GNEDFIRSQY
130 140 150 160 170 180
DANIKVVFAL GAEGDPVKSR EIQQDLVNEN KRFKDLIQQD FSDTFHNLTL KLLLQFGWVN
190 200 210 220 230 240
SFCPSAKFIM SADDDIFVHT PNLVSYLKSL PIETQDFWIG RVHRGSPPIR RKTSKYYVPY
250 260 270 280 290 300
EMYPWSSYPD YTAGAAYVVS RDVAAKVYEA SQTLNTSLYI DDVFMGICAN KMGLVPQYHV
310 320 330 340 350 360
FFSGEGKSPY HPCIYNKMMT SHGHLDDLDY LWRQAIDPNV KSISSGFWGN LYCRFVNIML
370
LCRISYVDTY PCSAAWS