Q5HZH2
Gene name |
Tsr3 |
Protein name |
18S rRNA aminocarboxypropyltransferase |
Names |
20S S rRNA accumulation protein 3 homolog |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:68327 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5HZH2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5HZH2-F1 | Predicted | AlphaFoldDB |
17 variants for Q5HZH2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389412037 | 5 | K>N | No | EVA | |
| rs107912418 | 17 | V>A | No | EVA | |
| rs3389435295 | 91 | Q>H | No | EVA | |
| rs13474875 | 103 | T>I | No | EVA | |
| rs3389445584 | 113 | L>V | No | EVA | |
| rs3389443311 | 142 | L>W | No | EVA | |
| rs3413159125 | 182 | V>P | No | EVA | |
| rs3389392743 | 211 | P>A | No | EVA | |
| rs3412776869 | 215 | L>S | No | EVA | |
| rs33774861 | 224 | S>N | No | EVA | |
| rs108558732 | 245 | V>A | No | EVA | |
| rs3389459538 | 268 | E>V | No | EVA | |
| rs3389442234 | 300 | T>N | No | EVA | |
| rs3389449854 | 303 | Q>R | No | EVA | |
| rs3389435299 | 305 | A>D | No | EVA | |
| rs3389445617 | 309 | D>E | No | EVA | |
| rs3389442192 | 322 | R>G | No | EVA |
No associated diseases with Q5HZH2
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| 18S rRNA aminocarboxypropyltransferase activity | Catalysis of the reaction: N1-methylpseudouridine in 18S rRNA + S-adenosyl-L-methionine = H+ + N1-methyl-N3-[(3S)-3-amino-3-carboxypropyl]pseudouridine in 18S rRNA + S-methyl-5'-thioadenosine. |
| S-adenosyl-L-methionine binding | Binding to S-adenosyl-L-methionine. |
| transferase activity | Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| enzyme-directed rRNA pseudouridine synthesis | The intramolecular conversion of uridine to pseudouridine during ribosome biogenesis where the enzyme specifies the site that becomes pseudouridylated without using a guide RNA. |
| maturation of SSU-rRNA | Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9UJK0 | TSR3 | 18S rRNA aminocarboxypropyltransferase | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGRKKVARGS | RKESGRVRRP | SGRSLDAFAE | EVGAALRASV | QPEEAEDQGG | PGPAALPCAL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AMWELGHCDP | KRCTGRKLAR | LGLVRCLRLS | QRFGGLVLSP | VGTEYVSPAD | RQLVAQSGVA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VIDCSWAKLD | DTPFQKMRGS | HLRLLPYLVA | ANPVNYGRPC | KLSCVEAFAA | AFCIVGFSDL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AVILLRKFKW | GKGFLDLNRE | LLDKYAACRG | PEEVLQAEQG | YLASTRDTPE | EDIDPFDVDS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GREFVNLNRP | VASTRLPEDM | DDTDGSEEHS | EDSEEDSDEC | EEPGPGANGG | DSNYSGAEET |
| 310 | 320 | ||||
| PEQEAQARDS | TEIWKGIKKR | QRD |