Q5HZE5

PR
Gene name
Tmem17
Protein name
Transmembrane protein 17
Names
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:360985
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-72 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5HZE5

Entry ID Method Resolution Chain Position Source
AF-Q5HZE5-F1 Predicted AlphaFoldDB

No variants for Q5HZE5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5HZE5

No associated diseases with Q5HZE5

No regional properties for Q5HZE5

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q5HZE5

Functions

Description
EC Number
Subcellular Localization
  • Cell projection, cilium membrane ; Multi-pass membrane protein
  • Localizes to the transition zone of primary cilia
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
ciliary membrane The portion of the plasma membrane surrounding a cilium.
ciliary transition zone A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition and separates the cytosol from the ciliary plasm.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
MKS complex A protein complex that is located at the ciliary transition zone and consists of several proteins some of which are membrane bound. Acts as an organiser of transition zone inner structure, specifically the Y-shaped links, in conjunction with the NPHP complex. The MKS complex also acts as part of the selective barrier that prevents diffusion of proteins between the ciliary cytoplasm and cellular cytoplasm as well as between the ciliary membrane and plasma membrane.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

3 GO annotations of biological process

Name Definition
cilium assembly The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
non-motile cilium assembly The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium.
smoothened signaling pathway The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q86X19 TMEM17 Transmembrane protein 17 Homo sapiens (Human) PR
Q8K0U3 Tmem17 Transmembrane protein 17 Mus musculus (Mouse) PR
10 20 30 40 50 60
MELPDPVRQR LSNLSLTMFG DSSRTGPESS EAADNEMVSS LPLQMSLYFN SYFFPLWWVS
70 80 90 100 110 120
CIVMLHLKYS VLPDYYKFIV ITVVILITLI EAIRLYLGCM GNLQEKVPEL AGFWLLSLLL
130 140 150 160 170 180
QLPLLLFLLL NEGLKNLPLE KAIHSIFTVF LTFQVISAFL TLKKMVNQLA ARFHLQDFDQ
190
LSASSATGRR ARQSSEEL