Q5HWF0

PR
Gene name
dxs
Protein name
1-deoxy-D-xylulose-5-phosphate synthase
Names
1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS
Species
Campylobacter jejuni (strain RM1221)
KEGG Pathway
cjr:CJE0366
EC number
2.2.1.7: Transketolases and transaldolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

57-126 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5HWF0

Entry ID Method Resolution Chain Position Source
AF-Q5HWF0-F1 Predicted AlphaFoldDB

No variants for Q5HWF0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5HWF0

No associated diseases with Q5HWF0

4 regional properties for Q5HWF0

Type Name Position InterPro Accession
domain Transketolase, N-terminal 28 - 47 IPR005474
domain Transketolase-like, pyrimidine-binding domain 309 - 473 IPR005475
binding_site Transketolase binding site 415 - 431 IPR020826
domain Transketolase, C-terminal domain 484 - 600 IPR033248

Functions

Description
EC Number 2.2.1.7 Transketolases and transaldolases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
1-deoxy-D-xylulose-5-phosphate synthase activity Catalysis of the reaction: D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO(2).
magnesium ion binding Binding to a magnesium (Mg) ion.
thiamine pyrophosphate binding Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases.

3 GO annotations of biological process

Name Definition
1-deoxy-D-xylulose 5-phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of 1-deoxy-D-xylulose 5-phosphate, the 5-phospho derivative of 1-deoxy-D-xylulose. 1-deoxy-D-xylulose 5-phosphate is an intermediate in the non-mevalonate pathway and a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis.
terpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure.
thiamine biosynthetic process The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSKKFVHTQE ELEKLSLKEL ENLAASMREK IIQVVSKNGG HLSSNLGAVE LSIAMHLVFD
70 80 90 100 110 120
AKKDPFIFDV SHQSYTHKLL SGKEEIFDTL RQINGLSGYT KPSEGDYFVA GHSSTSISLA
130 140 150 160 170 180
VGACKAIALK GEKRIPVALI GDGALSAGMA YEALNELGDS KFPCVILLND NEMSISKPIG
190 200 210 220 230 240
AISKYLSQAM ATQFYQSFKK RIAKMLDILP DSATYMAKRF EESFKLITPG LLFEELGLEY
250 260 270 280 290 300
IGPIDGHNLG EIISALKQAK AMQKPCVIHA QTIKGKGYVL AEGKHAKWHG VGAFDIDSGE
310 320 330 340 350 360
SVKKSDTKKS ATEIFSKNLL DLASKYENIV GVTAAMPSGT GLDKLIEKYP NRFWDVAIAE
370 380 390 400 410 420
QHAVTSMAAM AKEGFKPFIA IYSTFLQRAY DQVIHDCAIM NLNVVFAMDR AGIVGEDGET
430 440 450 460 470 480
HQGVFDLSFL APLPNFTLLA PRDEQMMQNI MEYAYLHQGP IAFRYPRGSF ILDKEFNPCE
490 500 510 520 530 540
IKLGKAQWLV KNSSEIAFLG YGQGVAKAWQ VLRALQEMNN NANLIDLIFA KPLDEELLCE
550 560 570 580 590 600
LAKKSKIWFI FSENVKIGGI ESLINNFLQK YDLHVKVVSF EYEDKFIEHG KTSEVEKNLE
610
KDVNSLLTKV LKFYH