Q5HUV1

PR
Gene name
gltX1
Protein name
Glutamate--tRNA ligase 1
Names
Glutamyl-tRNA synthetase 1, GluRS 1
Species
Campylobacter jejuni (strain RM1221)
KEGG Pathway
cjr:CJE0932
EC number
6.1.1.17: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

68-160 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5HUV1

Entry ID Method Resolution Chain Position Source
AF-Q5HUV1-F1 Predicted AlphaFoldDB

No variants for Q5HUV1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5HUV1

No associated diseases with Q5HUV1

3 regional properties for Q5HUV1

Type Name Position InterPro Accession
domain Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain 3 - 305 IPR020058
domain Glutamyl-tRNA synthetase 2 - 314 IPR033910
domain Aminoacyl-tRNA synthetase, class I, anticodon-binding 342 - 469 IPR045462

Functions

Description
EC Number 6.1.1.17 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
glutamate-tRNA ligase activity Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
glutamyl-tRNA aminoacylation The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. The glutamyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a glutamic acid-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MYRFAPSPTG DMHIGNLRAA IFNYICARQK NMDFILRIED TDKARNIAGK EEEIKEILNL
70 80 90 100 110 120
FSISWQHYYI QSENLKFHRQ MALKLVSEKK AFACFCTEEE LEAKKELAKK QGKAYRYDGT
130 140 150 160 170 180
CEKLADIDVL ECEKPFVIRL KKPTHTMKFT DFIKGELSFE PENIDSFVIM RTDKTPTYNF
190 200 210 220 230 240
ACAVDDMLEN VTCIIRGEDH VSNTPKQEHI RASLGYNKAM TYAHLPIILN EEGVKMSKRE
250 260 270 280 290 300
AHSSVKWLLE SGILPSAIAN YLIMLGNKTP CEIFTLEKAI KWFDISKVSK APARFDLKKL
310 320 330 340 350 360
LQINREHIKM IKDDELNKIL DLNKDLAPLA KFYTQEASTI KELKEKMQAI FNAKNFGEFE
370 380 390 400 410 420
TECKILKELL KDIELFENYE DFKNELLNKS NLKGKKFFMP LRIILTGNIH GPELSDLYPY
430
IKNFIHELAR I