Q5HRQ2
Gene name |
mfd |
Protein name |
Transcription-repair-coupling factor |
Names |
TRCF |
Species |
Staphylococcus epidermidis (strain ATCC 35984 / RP62A) |
KEGG Pathway |
ser:SERP0141 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5HRQ2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5HRQ2-F1 | Predicted | AlphaFoldDB |
No variants for Q5HRQ2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5HRQ2 | |||||
No associated diseases with Q5HRQ2
6 regional properties for Q5HRQ2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Helicase, C-terminal | 809 - 970 | IPR001650 |
| domain | CarD-like/TRCF, RNAP-interacting domain | 495 - 592 | IPR003711 |
| domain | Transcription-repair-coupling factor, C-terminal domain | 1021 - 1121 | IPR005118 |
| domain | DEAD/DEAH box helicase domain | 621 - 780 | IPR011545 |
| domain | Helicase superfamily 1/2, ATP-binding domain | 616 - 806 | IPR014001 |
| domain | UvrB, interaction domain | 140 - 227 | IPR041471 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| damaged DNA binding | Binding to damaged DNA. |
| helicase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix. |
| hydrolase activity | Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| regulation of DNA-templated transcription | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
| transcription-coupled nucleotide-excision repair, DNA damage recognition | The identification of lesions on the actively transcribed strand of the DNA duplex as well as a small subset of lesions not recognized by the general nucleotide-excision repair pathway. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKSMIANYIS | EDNRFQELDE | VFGQENILVT | GLSPSAKATI | IAEKYLKDHK | QMLLVTNNLY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QADKIETDIL | QYVDDSEVYK | YPVQDIMTEE | FSTQSPQLMS | ERVRTLTALA | QGEKGLFIVP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LNGFKKWLTP | VDLWKDHQMT | LKVGQDIDVD | AFLNKLVNMG | YRRESVVSHI | GEFSLRGGII |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DIYPLIGTPV | RIELFDTEVD | SIRDFDVETQ | RSNDNINQVE | ITTASDYIIT | DEVIQHLQNE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LKKAYEYTRP | KIEKSVRNDL | KETYESFKLF | ESTFFDHQLL | RRLVSFMYEK | PSTLIDYFQK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NAIIVVDEFN | RIKETEETLT | TEVEDFMSNL | IESGNGFIGQ | GFMKYESFDA | LLEQHAVAYF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TLFTSSMQVP | LQHIIKFSCK | PVQQFYGQYD | IMRSEFQRYV | HQDYTVVVLV | ETETKVERIQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SMLNEMHIPT | VSNIHEDIDG | GQVVVTEGSL | SEGFELPYMQ | LVVITERELF | KTRQKKQRKR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| TKTISNAEKI | KSYQDLNVGD | YIVHVHHGVG | RYLGVETLEV | GDTHRDYIKL | QYKGTDQLFV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| PVDQMDQVQK | YVASEDKSPR | LNKLGGTEWK | KTKAKVQQSV | EDIADELIDL | YKEREMSVGY |
| 610 | 620 | 630 | 640 | 650 | 660 |
| QYGQDTAEQS | AFEHDFPYEL | TPDQSKSIDE | IKGDMERARP | MDRLLCGDVG | YGKTEVAVRA |
| 670 | 680 | 690 | 700 | 710 | 720 |
| AFKAVMDGKQ | VAFLVPTTIL | AQQHYETLLE | RMQDFPVEIQ | LVSRFRTAKE | IRETKEGLKS |
| 730 | 740 | 750 | 760 | 770 | 780 |
| GYVDIVVGTH | KLLGKDIQYK | DLGLLIVDEE | QRFGVRHKER | IKTLKKNVDV | LTLTATPIPR |
| 790 | 800 | 810 | 820 | 830 | 840 |
| TLHMSMLGVR | DLSVIETPPE | NRFPVQTYVL | EQNTNFIKEA | LERELSRDGQ | VFYLYNKVQS |
| 850 | 860 | 870 | 880 | 890 | 900 |
| IYEKREQLQR | LMPDANIAVA | HGQMTERDLE | ETMLSFINHE | YDILVTTTII | ETGVDVPNAN |
| 910 | 920 | 930 | 940 | 950 | 960 |
| TLIIEEADRF | GLSQLYQLRG | RVGRSSRIGY | AYFLHPANKV | LNETAEERLQ | AIKEFTELGS |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| GFKIAMRDLN | IRGAGNLLGK | QQHGFIDSVG | FDLYSQMLEE | AVNEKRGIKE | ESPDAPDIEV |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| ELHLDAYLPA | EYIQSEQAKI | EIYKKLRKVE | TEEQLFDVKD | ELIDRFNDYP | IEVERLLDIV |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| EIKVHALHAG | VELIKDKGKS | IQIILSPKAT | EDINGEELFK | QTQPLGRAMK | VGVQNNAMNV |
| 1150 | 1160 | ||||
| TLTKSKQWLD | SLKFLVRCIE | ESMAIKDED |