Q5HNR8

PR
Gene name
relA (SERP1196)
Protein name
GTP pyrophosphokinase
Names
(p)ppGpp synthase, ATP:GTP 3'-pyrophosphotransferase, ppGpp synthase I
Species
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
KEGG Pathway
ser:SERP1196
EC number
2.7.6.5: Diphosphotransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

531-609 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5HNR8

Entry ID Method Resolution Chain Position Source
AF-Q5HNR8-F1 Predicted AlphaFoldDB

No variants for Q5HNR8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5HNR8

No associated diseases with Q5HNR8

7 regional properties for Q5HNR8

Type Name Position InterPro Accession
domain ACT domain 649 - 729 IPR002912
domain HD/PDEase domain 46 - 171 IPR003607
domain TGS 393 - 454 IPR004095
domain HD domain 50 - 149 IPR006674
domain RelA/SpoT 220 - 350 IPR007685
domain RelA/SpoT, TGS domain 396 - 454 IPR033655
domain RelA/SpoT, AH and RIS domains 468 - 632 IPR045600

Functions

Description
EC Number 2.7.6.5 Diphosphotransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GTP binding Binding to GTP, guanosine triphosphate.
GTP diphosphokinase activity Catalysis of the reaction: ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate.
kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.

2 GO annotations of biological process

Name Definition
guanosine tetraphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNNEYPYSAD EVLYKAKSYL STSEYEYVLK SYHIAYEAHK GQFRKNGLPY IMHPIQVAGI
70 80 90 100 110 120
LTEMRLDGPT IVAGFLHDVI EDTSYTFEDV KDMFNEEIAR IVDGVTKLKK VKYRSKEEQQ
130 140 150 160 170 180
AENHRKLFIA IAKDVRVILV KLADRLHNMR TLKAMPREKQ VRISKETLEI YAPLAHRLGI
190 200 210 220 230 240
NTIKWELEDT ALRYIDSVQY FRIVNLMKKK RSEREAYITN AINKIKNEMT KMNLSGEING
250 260 270 280 290 300
RPKHIYSIYR KMIKQKKQFD QIFDLLAIRI IVNSINDCYA TLGLVHTLWK PMPGRFKDYI
310 320 330 340 350 360
AMPKQNMYQS LHTTVVGPNG DPLEIQIRTH EMHEIAEHGV AAHWAYKEGK TVNQKTQDFQ
370 380 390 400 410 420
NKLNWLKELA ETDHTSADAQ EFMESLKYDL QSDKVYAFTP ASDVIELPYG AVPIDFAYAI
430 440 450 460 470 480
HSEVGNKMIG AKVNGKIVPI DYVLQTGDII EIRTSKHSYG PSRDWLKIVK SSSAKSKIKS
490 500 510 520 530 540
FFKKQDRSSN IEKGKFMVEA EIKEQGFRVE DILTEKNLEV VNEKYHFAND EDLYAAVGFG
550 560 570 580 590 600
GVTSIQIVNK LTERQRILDK QKALNEAQEV TKSVPIKKDI TTDSGVYVEG LENVLIKLSK
610 620 630 640 650 660
CCNPIPGDDI VGYITKGHGI KVHRTDCPNI KNETDRLISV EWVKSKDSTQ QYQVDLEVTA
670 680 690 700 710 720
YDRNGLLNEV LQAVNSTAGS LIKVSGRSDI DKNAVINISV MVKNVNDVYR VVEKIKQLGD
VYTVSRVWN