Q5HGY9
Gene name |
pdhC (SACOL1104) |
Protein name |
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex |
Names |
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex, E2 |
Species |
Staphylococcus aureus (strain COL) |
KEGG Pathway |
sac:SACOL1104 |
EC number |
2.3.1.12: Transferring groups other than amino-acyl groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5HGY9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5HGY9-F1 | Predicted | AlphaFoldDB |
No variants for Q5HGY9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5HGY9 | |||||
No associated diseases with Q5HGY9
9 regional properties for Q5HGY9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | PAS domain | 537 - 606 | IPR000014-1 |
| domain | PAS domain | 659 - 782 | IPR000014-2 |
| domain | Histidine kinase/HSP90-like ATPase | 910 - 1031 | IPR003594 |
| domain | Signal transduction histidine kinase, dimerisation/phosphoacceptor domain | 793 - 864 | IPR003661 |
| domain | Signal transduction histidine kinase-related protein, C-terminal | 948 - 962 | IPR004358-1 |
| domain | Signal transduction histidine kinase-related protein, C-terminal | 991 - 1009 | IPR004358-2 |
| domain | Signal transduction histidine kinase-related protein, C-terminal | 1015 - 1028 | IPR004358-3 |
| domain | Histidine kinase domain | 802 - 1031 | IPR005467 |
| domain | PAS fold | 661 - 716 | IPR013767 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.3.1.12 | Transferring groups other than amino-acyl groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| dihydrolipoyllysine-residue acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + dihydrolipoamide = CoA + S-acetyldihydrolipoamide. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| glycolytic process | The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAFEFRLPDI | GEGIHEGEIV | KWFVKAGDTI | EEDDVLAEVQ | NDKSVVEIPS | PVSGTVEEVM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VEEGTVAVVG | DVIVKIDAPD | AEDMQFKGHD | DDSSSKEEPA | KEEAPAEQAP | VATQTEEVDE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NRTVKAMPSV | RKYAREKGVN | IKAVSGSGKN | GRITKEDVDA | YLNGGAPTAS | NESAASATSE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EVAETPAAPA | AVTLEGDFPE | TTEKIPAMRR | AIAKAMVNSK | HTAPHVTLMD | EIDVQALWDH |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RKKFKEIAAE | QGTKLTFLPY | VVKALVSALK | KYPALNTSFN | EEAGEIVHKH | YWNIGIAADT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DRGLLVPVVK | HADRKSIFQI | SDEINELAVK | ARDGKLTADE | MKGATCTISN | IGSAGGQWFT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PVINHPEVAI | LGIGRIAQKP | IVKDGEIVAA | PVLALSLSFD | HRQIDGATGQ | NAMNHIKRLL |
| NNPELLLMEG |