AiPD: Autoinhibited Protein Database

Q5H9I0

Gene name	TFDP3 (DP4, HCA661)
Protein name	Transcription factor Dp family member 3
Names	Cancer/testis antigen 30, CT30, Hepatocellular carcinoma-associated antigen 661
Species	Homo sapiens (Human)
KEGG Pathway	hsa:51270
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

55-128 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

55-128 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q5H9I0

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q5H9I0-F1	Predicted				AlphaFoldDB

279 variants for Q5H9I0

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA10520269 rs747668464	2	A>E		No	ClinGen ExAC gnomAD
CA414702001 rs747668464	2	A>G		No	ClinGen ExAC gnomAD
rs187566474 CA10520268	4	Y>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA414701935 rs1250096149	6	S>C		No	ClinGen gnomAD
CA335942584 rs200002834	6	S>N		No	ClinGen TOPMed gnomAD
CA414701890 rs1483936475	9	E>G		No	ClinGen gnomAD
rs753663130 CA10520266	10	A>P		No	ClinGen ExAC TOPMed gnomAD
rs1211301075 CA414701843	11	N>T		No	ClinGen gnomAD
rs1188517610 CA414701793	13	E>*		No	ClinGen TOPMed
CA414701650 rs1421487730	18	M>T		No	ClinGen TOPMed
rs28455963 CA10520262	20	E>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1603031264 CA414701540	23	T>I		No	ClinGen Ensembl
CA414701556 rs1305891879	23	T>P		No	ClinGen gnomAD
CA10520261 rs752829662	25	R>H		No	ClinGen ExAC TOPMed gnomAD
CA10520260 rs752829662	25	R>L		No	ClinGen ExAC TOPMed gnomAD
rs1459645116 CA414701473	27	V>M		No	ClinGen TOPMed
TCGA novel	27	V>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM1155269 rs777030815 CA10520257	29	V>I	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs866188727 CA335942583	31	T>I		No	ClinGen Ensembl
rs771151026 CA10520256	32	S>P		No	ClinGen ExAC gnomAD
rs772720656 CA10520253	34	V>A		No	ClinGen ExAC TOPMed gnomAD
rs773790494 CA10520254	34	V>L		No	ClinGen ExAC gnomAD
CA10520255 rs773790494 COSM1145563	34	V>M	lung large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs774072067 CA10520251	36	P>L		No	ClinGen ExAC TOPMed gnomAD
CA10520252 rs774072067	36	P>R		No	ClinGen ExAC TOPMed gnomAD
CA335942580 rs1029271555	37	L>F		No	ClinGen TOPMed
CA335942579 rs748945772 CA10520249	38	G>R		No	ClinGen ExAC gnomAD
rs779782280 CA10520248	40	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs1259689634 CA414701226	40	Q>P		No	ClinGen gnomAD
rs1218653884 CA414701207	41	L>H		No	ClinGen gnomAD
CA10520245 rs781090348	43	P>L		No	ClinGen ExAC TOPMed gnomAD
CA10520246 rs745673311	43	P>S		No	ClinGen ExAC gnomAD
rs367795076 CA10520244	44	K>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1340204533 CA414701120	46	F>S		No	ClinGen gnomAD
CA414701014 rs1233070888	50	S>R		No	ClinGen gnomAD
CA335942578 rs936104850	52	N>S		No	ClinGen TOPMed gnomAD
CA414700917 rs1280680740	55	Q>*		No	ClinGen gnomAD
rs926054162 CA335942577	55	Q>L		No	ClinGen TOPMed
CA10520242 rs752737964	57	V>A		No	ClinGen ExAC gnomAD
CA335942576 rs979696816	59	I>T		No	ClinGen TOPMed
rs371634842 CA10520241	61	M>I		No	ClinGen ExAC TOPMed gnomAD
CA10520239 rs753965765	63	Q>H		No	ClinGen ExAC gnomAD
CA335942575 rs868551185	66	A>E		No	ClinGen Ensembl
rs766626788 CA335942574	67	A>S		No	ClinGen ExAC gnomAD
rs766626788 CA10520238	67	A>T		No	ClinGen ExAC gnomAD
CA414700665 rs1474776490	67	A>V		No	ClinGen gnomAD
CA414700647 rs1313668986	69	N>D		No	ClinGen gnomAD
rs1569329130 CA414700606	71	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA10520235 rs200465931	73	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs773893894 CA10520234	76	P>L		No	ClinGen ExAC gnomAD
rs773893894 CA10520233	76	P>R		No	ClinGen ExAC gnomAD
CA335942572 rs368319334	77	N>H		No	ClinGen ESP TOPMed gnomAD
rs1273428174 CA414700528	77	N>K		No	ClinGen gnomAD
CA414700543 rs368319334	77	N>Y		No	ClinGen ESP TOPMed gnomAD
CA10520232 rs201974352	79	P>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs748864765 CA10520231	80	S>T		No	ClinGen ExAC gnomAD
rs867026564 CA335942571	83	F>S		No	ClinGen TOPMed gnomAD
CA414700424 rs1402302586	84	A>V		No	ClinGen TOPMed
rs906109582 CA335942570	85	S>F		No	ClinGen TOPMed gnomAD
rs774940932 CA10520230	86	Q>*		No	ClinGen ExAC gnomAD
CA414700377 rs1371770692	88	Q>*		No	ClinGen gnomAD
TCGA novel	91	Y>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
COSM1664539 CA414700310 rs1402694634	92	S>F	kidney [Cosmic]	No	ClinGen cosmic curated gnomAD
rs745533547 CA10520222	94	P>L		No	ClinGen 1000Genomes ExAC
rs769633313 CA10520223	94	P>S		No	ClinGen 1000Genomes ExAC gnomAD
rs780665772 CA10520221	95	P>L		No	ClinGen 1000Genomes ExAC gnomAD
CA335942569 rs950249154	95	P>S		No	ClinGen gnomAD
rs753967248 CA10520220	96	W>*		No	ClinGen ExAC TOPMed gnomAD
rs1252224454 CA414700162 CA414700160	100	H>Q		No	ClinGen TOPMed gnomAD
TCGA novel	102	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10520218 rs756471402	104	G>E		No	ClinGen ExAC gnomAD
CA10520217 rs200184256	105	E>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA414700043 rs1164977468	106	K>E		No	ClinGen gnomAD
CA10520216 rs768047382	106	K>N		No	ClinGen ExAC gnomAD
CA414699995 rs1253380221	108	G>S		No	ClinGen gnomAD
CA10520215 rs374029681	109	M>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs762980759 CA335942567	110	G>S		No	ClinGen Ensembl
CA414699912 rs1302825657	113	R>G		No	ClinGen TOPMed gnomAD
CA10520213 rs764669689	113	R>H		No	ClinGen ExAC gnomAD
CA335942565 rs764669689	113	R>L		No	ClinGen ExAC gnomAD
TCGA novel	113	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs762353487 CA10520212	114	L>F		No	ClinGen ExAC gnomAD
rs1329723930 CA414699890	114	L>P		No	ClinGen gnomAD
CA10520211 rs751008224	115	S>A		No	ClinGen 1000Genomes ExAC gnomAD
rs759231182 CA10520209	119	W>R		No	ClinGen ExAC gnomAD
CA414699733 COSM3973261 rs1239930035	121	T>M	kidney Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA414699720 rs1338479703	122	V>E		No	ClinGen gnomAD
rs777511666 CA10520205	127	T>A		No	ClinGen ExAC gnomAD
rs772108089 CA10520204	130	C>*		No	ClinGen ExAC TOPMed gnomAD
CA414699571 rs1365194831	130	C>F		No	ClinGen gnomAD
CA414699565 rs772108089	130	C>W		No	ClinGen ExAC TOPMed gnomAD
CA335942564 rs984408004	131	Q>E		No	ClinGen TOPMed gnomAD
TCGA novel	133	V>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10520203 rs749325749	133	V>L		No	ClinGen ExAC gnomAD
CA10520200 rs373866552	136	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs757631601 CA10520198	139	A>P		No	ClinGen ExAC TOPMed gnomAD
rs751969445 CA10520197	140	K>R		No	ClinGen ExAC TOPMed gnomAD
CA414699369 rs1238536581	141	F>L		No	ClinGen gnomAD
CA10520196 rs199687528	143	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA414699317 rs1445029485	145	S>N		No	ClinGen TOPMed
CA414699284 rs1353453238	147	H>R		No	ClinGen TOPMed
CA10520195 rs61732904	147	H>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10520193 rs765029523 COSM1569691	148	A>T	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA gnomAD
CA10520192 rs759077593	148	A>V		No	ClinGen ExAC gnomAD
CA414699257 rs1342946300	149	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs770582451 CA10520190	150	P>A		No	ClinGen ExAC TOPMed gnomAD
CA414699247 rs1158617618	150	P>L		No	ClinGen gnomAD
rs770582451 CA10520191	150	P>S		No	ClinGen ExAC TOPMed gnomAD
rs759259683 CA10520188	151	N>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1361706276 CA414699227	152	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs754122896 CA10520187	156	D>G		No	ClinGen 1000Genomes ExAC gnomAD
rs369636843 CA10520186	157	V>M		No	ClinGen ESP ExAC TOPMed
rs372952881 CA10520184	160	I>M		No	ClinGen ESP ExAC gnomAD
rs376036313 CA10520185	160	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1569328988 CA414699118	161	K>E		No	ClinGen Ensembl
CA10520182 COSM1598841 rs745953075	163	R>C	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA10520181 rs781509777	163	R>H		No	ClinGen ExAC
rs1446542251 CA414699076	164	T>I		No	ClinGen TOPMed gnomAD
TCGA novel	167	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1465081689 CA414699031	167	A>V		No	ClinGen TOPMed
rs545226775 CA335942563	168	L>F		No	ClinGen Ensembl
CA10520177 rs758709168	171	L>V		No	ClinGen ExAC gnomAD
CA10520176 rs147545090	172	M>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	173	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1292623438 CA414698931	174	M>I		No	ClinGen gnomAD
CA10520175 rs149400555	174	M>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs372789532 CA10520174	175	N>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs768142194 CA335942562	177	I>V		No	ClinGen TOPMed
TCGA novel	179	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	182	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA414698814 rs1318485406	183	K>E		No	ClinGen gnomAD
rs766017508 CA10520171	185	K>N		No	ClinGen ExAC TOPMed gnomAD
rs753402635 CA10520172 COSM1556607	185	K>R	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs369687070 CA10520169	190	T>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA414698710 rs1251917111	191	T>A		No	ClinGen TOPMed
CA414698684 rs767295052	192	N>I		No	ClinGen ExAC TOPMed gnomAD
rs1476694726 CA414698679	192	N>K		No	ClinGen gnomAD
CA335942561 rs767295052	192	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA10520168 rs767295052	192	N>T		No	ClinGen ExAC TOPMed gnomAD
CA414698668 rs1243191435	193	S>L		No	ClinGen gnomAD
rs761547932 CA10520167	194	A>V		No	ClinGen ExAC gnomAD
CA10520165 rs35745873 CA10520166	195	Q>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1257404233 CA414698634	195	Q>L		No	ClinGen TOPMed
CA10520164 rs745932397	200	L>F		No	ClinGen ExAC gnomAD
rs776887298 CA414698561	201	R>G		No	ClinGen ExAC TOPMed gnomAD
rs184162475 CA414698560	201	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10520162 rs184162475	201	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs776887298 COSM1625528 CA10520163	201	R>W	liver [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs747201504 CA10520161	202	V>G		No	ClinGen ExAC gnomAD
CA414698515 rs1193470914	204	R>K		No	ClinGen TOPMed
rs572354829 CA10520160	205	Q>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs748525964 CA10520158	208	L>H		No	ClinGen ExAC TOPMed gnomAD
CA10520159 rs748525964	208	L>P		No	ClinGen ExAC TOPMed gnomAD
rs779376906 CA10520157	210	R>K		No	ClinGen ExAC gnomAD
rs372437742 CA10520156	210	R>S		No	ClinGen ExAC TOPMed gnomAD
CA414698335 rs1362352762	215	Q>H		No	ClinGen gnomAD
rs1267701291 CA414698331	216	S>P		No	ClinGen gnomAD
rs1327524181 CA414698307	217	E>D		No	ClinGen gnomAD
CA414698239 rs1393232272	222	I>F		No	ClinGen gnomAD
CA414698230 rs1389056389	222	I>M		No	ClinGen TOPMed
rs1295616767 CA414698235	222	I>T		No	ClinGen TOPMed
rs368393446 CA10520154	223	L>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
rs374639205 CA10520153	224	Q>*		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	225	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1291280395 CA414698161	227	A>V		No	ClinGen gnomAD
rs767085124 CA10520151	229	K>R		No	ClinGen ExAC TOPMed gnomAD
CA10520150 rs761613082	230	N>K		No	ClinGen ExAC gnomAD
rs1468258210 CA414698106	232	V>E		No	ClinGen gnomAD
rs926526206 CA335942560	232	V>M		No	ClinGen TOPMed gnomAD
CA414698062 rs1308973572	236	Q>*		No	ClinGen gnomAD
rs774348613 CA10520149	237	Y>H		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	240	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs763031638 CA10520147	240	E>D		No	ClinGen ExAC gnomAD
rs367669821 CA10520148	240	E>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA414698013 rs1213873379	240	E>K		No	ClinGen gnomAD
rs367669821 CA414698007	240	E>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1440993574 CA414697953	245	R>Q		No	ClinGen TOPMed gnomAD
CA10520146 rs746359549	246	P>L		No	ClinGen ExAC TOPMed gnomAD
CA335942559 rs746359549	246	P>R		No	ClinGen ExAC TOPMed gnomAD
CA10520145 rs770998600	249	N>S		No	ClinGen ExAC gnomAD
CA10520143 rs373819303	251	V>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA10520144 rs373819303	251	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA10520142 rs192032791	253	H>P		No	ClinGen 1000Genomes ExAC gnomAD
CA414697855 rs192032791	253	H>R		No	ClinGen 1000Genomes ExAC gnomAD
CA335942558 COSM1598842 rs865906208	254	V>M	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated Ensembl NCI-TCGA
rs950321068 CA335942557	255	P>A		No	ClinGen TOPMed
TCGA novel	256	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10520140 rs779291058	257	I>V		No	ClinGen ExAC gnomAD
rs755458616 CA10520139	258	I>N		No	ClinGen ExAC gnomAD
CA10520138 rs749746922	259	I>S		No	ClinGen ExAC TOPMed gnomAD
CA414697782 rs1453814338	259	I>V		No	ClinGen gnomAD
TCGA novel	260	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs780457581 CA10520137	261	S>N		No	ClinGen ExAC gnomAD
rs755588251 CA10520136	263	K>R		No	ClinGen ExAC gnomAD
CA335942556 rs962419435	265	T>N		No	ClinGen TOPMed
CA10520134 rs767188782	266	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA414697669 rs1282360197	267	I>T		No	ClinGen gnomAD
CA10520133 rs756929660	267	I>V		No	ClinGen ExAC TOPMed gnomAD
CA414697659 rs1457767230	268	N>T		No	ClinGen TOPMed
rs1362730752 CA414697604	272	S>F		No	ClinGen TOPMed
CA414697601 rs1363372407	273	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA10520128 rs370913906	274	D>N		No	ClinGen ESP ExAC gnomAD
CA10520129 rs370913906	274	D>Y		No	ClinGen ESP ExAC gnomAD
CA414697555 rs1297604942	276	S>*		No	ClinGen TOPMed
CA414697530 rs1373571114	278	Y>F		No	ClinGen gnomAD
TCGA novel	279	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	280	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1048754786 CA335942554	281	K>R		No	ClinGen Ensembl
CA414697481 rs1229894276	282	F>L		No	ClinGen TOPMed
rs760796084 CA10520127	287	E>K		No	ClinGen ExAC gnomAD
rs773230302 CA10520126	289	H>D		No	ClinGen ExAC gnomAD
CA335942553 rs998351947	290	D>G		No	ClinGen TOPMed gnomAD
rs762072463 CA335942552	291	D>N		No	ClinGen ExAC gnomAD
CA10520124 rs762072463	291	D>Y		No	ClinGen ExAC gnomAD
rs1357454317 CA414697291	294	V>M		No	ClinGen gnomAD
CA414697054 rs1287680881	301	T>S		No	ClinGen TOPMed
CA414696984 rs1487081777	304	L>P		No	ClinGen TOPMed
CA10520121 rs376822661	306	S>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs930328053 CA335942550	306	S>P		No	ClinGen Ensembl
rs1469511193 CA414696932	307	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs770264201 CA10520119	308	S>G		No	ClinGen ExAC TOPMed gnomAD
CA10520118 rs780612876	309	C>W		No	ClinGen ExAC gnomAD
CA414696885 rs1184093450	309	C>Y		No	ClinGen TOPMed
CA414696831 rs1211455832	311	A>V		No	ClinGen gnomAD
TCGA novel	312	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs751213260 CA10520115	314	L>F		No	ClinGen ExAC gnomAD
CA414696768 rs1217306538	314	L>R		No	ClinGen gnomAD
CA414696718 rs1382576771	316	M>L		No	ClinGen TOPMed
CA414696716 rs1200788317	316	M>T		No	ClinGen gnomAD
rs777568015 CA10520114	318	R>K		No	ClinGen ExAC TOPMed gnomAD
CA414696579 rs1305779426	322	P>L		No	ClinGen gnomAD
rs1158277908 CA414696592	322	P>S		No	ClinGen TOPMed
CA10520113 rs758208285	323	K>Q		No	ClinGen ExAC gnomAD
COSM1598844 rs752491742 CA10520112	327	P>L	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA10520109 rs750495166	329	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1268478871 CA414696465	331	E>K		No	ClinGen gnomAD
CA414696434 rs1489317436	332	M>I		No	ClinGen gnomAD
CA414696440 rs1217577028	332	M>L		No	ClinGen gnomAD
rs767448986 CA10520108	334	Q>*		No	ClinGen ExAC gnomAD
TCGA novel	335	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10520107 rs761912849	339	G>D		No	ClinGen ExAC TOPMed gnomAD
rs1344842659 CA414696339	339	G>S		No	ClinGen gnomAD
CA335942549 rs761912849	339	G>V		No	ClinGen ExAC TOPMed gnomAD
CA414696328 rs1419697552	341	F>L		No	ClinGen TOPMed gnomAD
rs768883137 CA10520105	350	G>D		No	ClinGen ExAC TOPMed gnomAD
CA414696260 rs1206385987	351	T>M		No	ClinGen gnomAD
CA414696265 rs1259819041	351	T>P		No	ClinGen gnomAD
rs775789413 CA10520103	352	W>*		No	ClinGen ExAC gnomAD
rs1320497384 CA414696234	355	A>V		No	ClinGen gnomAD
rs141896027 CA10520102	356	S>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA414696221 rs1240341171	357	D>V		No	ClinGen TOPMed
rs749286965 CA10520100	361	I>T		No	ClinGen ExAC TOPMed gnomAD
rs199819175 CA10520099	362	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA414696189 rs1443444150	362	A>V		No	ClinGen gnomAD
rs746528072 CA10520098	363	I>T		No	ClinGen ExAC gnomAD
CA414696187 rs1165455706	363	I>V		No	ClinGen gnomAD
rs188914178 CA335942548	364	G>E		No	ClinGen 1000Genomes
CA335942547 rs1033100044	365	M>V		No	ClinGen Ensembl
rs777553396 CA10520097	367	A>D		No	ClinGen ExAC gnomAD
rs1603030456 CA414696155	368	T>R		No	ClinGen Ensembl
CA414696140 rs1246938572	370	S>F		No	ClinGen gnomAD
rs372309436 CA10520094	371	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs754825609 CA10520092	373	S>C		No	ClinGen ExAC gnomAD
TCGA novel	374	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs369481531 CA335942545	375	Y>*		No	ClinGen ESP TOPMed
rs1333293488 CA414696114	375	Y>H		No	ClinGen TOPMed
CA335942544 COSM1155266 rs1044980404	377	G>D	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA10520090 rs766310359	381	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs1228729650 CA414696063 COSM1145560	383	P>T	lung [Cosmic]	No	ClinGen cosmic curated gnomAD
CA414696049 rs1307404243	385	V>I		No	ClinGen gnomAD
rs867144304 CA335942543	386	E>K		No	ClinGen gnomAD
rs1277221204 CA414696016	389	E>V		No	ClinGen TOPMed
rs1325395592 CA414695997	392	D>N		No	ClinGen gnomAD
CA10520086 COSM1598846 rs375672208	395	D>N	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP NCI-TCGA TOPMed
rs183061934 CA414695959 CA414695960	396	D>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1456702986 CA414695965	396	D>N		No	ClinGen TOPMed
TCGA novel	397	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs775801098 CA10520083	399	S>R		No	ClinGen ExAC gnomAD
CA10520082 rs765474569	403	E>K		No	ClinGen ExAC gnomAD

No associated diseases with Q5H9I0

2 regional properties for Q5H9I0

Type	Name	Position	InterPro Accession
domain	E2F/DP family, winged-helix DNA-binding domain	106 - 188	IPR003316
domain	Transcription factor DP, C-terminal	193 - 340	IPR014889

Functions

		Description
EC Number
Subcellular Localization	Nucleus Cytoplasm	Translocates to the nucleus on heterodimerization with E2F family members
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
chromatin	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
transcription regulator complex	A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.

4 GO annotations of molecular function

Name	Definition
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-binding transcription factor binding	Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription.
RNA polymerase II-specific DNA-binding transcription factor binding	Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription.
transcription regulator inhibitor activity	A molecular function regulator that inhibits the activity of a transcription regulator via direct binding and/or post-translational modification.

5 GO annotations of biological process

Name	Definition
cellular response to DNA damage stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
G1/S transition of mitotic cell cycle	The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated.
negative regulation of DNA-binding transcription factor activity	Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
negative regulation of G1/S transition of mitotic cell cycle	Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.
regulation of transcription by RNA polymerase II	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MAKYVSLTEA	NEELKVLMDE	NQTSRPVAVH	TSTVNPLGKQ	LLPKTFGQSS	VNIDQQVVIG
70	80	90	100	110	120
MPQRPAASNI	PVVGSPNPPS	THFASQNQHS	YSSPPWAGQH	NRKGEKNGMG	LCRLSMKVWE
130	140	150	160	170	180
TVQRKGTTSC	QEVVGELVAK	FRAASNHASP	NESAYDVKNI	KRRTYDALNV	LMAMNIISRE
190	200	210	220	230	240
KKKIKWIGLT	TNSAQNCQNL	RVERQKRLER	IKQKQSELQQ	LILQQIAFKN	LVLRNQYVEE
250	260	270	280	290	300
QVSQRPLPNS	VIHVPFIIIS	SSKKTVINCS	ISDDKSEYLF	KFNSSFEIHD	DTEVLMWMGM
310	320	330	340	350	360
TFGLESGSCS	AEDLKMARNL	VPKALEPYVT	EMAQGTFGGV	FTTAGSRSNG	TWLSASDLTN
370	380	390	400
IAIGMLATSS	GGSQYSGSRV	ETPAVEEEEE	EDNNDDDLSE	NDEDD