Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for Q5H8A6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 6O6J | X-ray | 160 A | A | 312-853 | PDB |
| 6O7A | X-ray | 330 A | A/B/C/D | 312-853 | PDB |
| 6O7C | X-ray | 185 A | A | 312-853 | PDB |
| AF-Q5H8A6-F1 | Predicted | AlphaFoldDB |
No variants for Q5H8A6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5H8A6 | |||||
No associated diseases with Q5H8A6
1 regional properties for Q5H8A6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | CASTOR/POLLUX/SYM8 ion channel, conserved domain | 463 - 561 | IPR010420 |
Functions
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| nuclear membrane | Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| ion transport | The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSLDSEVSVS | SSSGRDWFFP | SPSFFRSSPS | QYGRRFHTNS | NTHSAPSSTY | PSGIRHRRRV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KFSRTPTTSS | NEKPQISIVS | DKPSAISKNN | LNWLSQFGLQ | FALVTLTIVF | LLLLLLRNTH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LESQVNKLQG | EILRLHACHQ | LDTLNVSSST | AHKSQDTHPC | SCENFKRNLA | LFLSFMLLLI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PLIIFKYIDY | VSRSRLSENI | SEQVSLNKQI | AYRVDVFLSV | YPYAKPLVLL | VATLLLIFLG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GLTLFGVTTE | DLGHCLWLSW | TYVADSGNHA | SSEGIGPRLV | AVSISFGGML | IFAMMLGLVS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DAISEKFDSL | RKGKSEVVEQ | NHTLILGWSD | KLGSLLNQLA | IANESLGGGT | IAVMAERDKE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DMELDIGKME | FDFKGTSVIC | RSGSPLILAD | LKKVSVSKAR | TIIVLAEDGN | ADQSDARALR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TVLSLTGVKE | GLRGHIVVEM | SDLDNEVLVK | LVGGDLVETV | VAHDVIGRLM | IQCARQPGLA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QIWEDILGFE | NCEFYIKRWP | QLDGMLFEDV | LISFPAAIPC | GIKVASYGGK | IILNPDDSYV |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LQEGDEVLVI | AEDDDTYAPA | PLPMVRRGSL | PKDFVYPKSP | ERILFCGWRR | DMEDMITVLD |
| 610 | 620 | 630 | 640 | 650 | 660 |
| ASLAPDSELW | MFNDVPEKER | EKKLIDGGLD | ISRLENISLV | NREGNAVIRR | HLESLPLESF |
| 670 | 680 | 690 | 700 | 710 | 720 |
| DSILILADES | VEDSAIQADS | RSLATLLLIR | DIQARRLPYV | AMASQTQGGN | FSKGSWIGEM |
| 730 | 740 | 750 | 760 | 770 | 780 |
| KQASDKTVII | SEILDPRTKN | LLSMSKISDY | VLSNELVSMA | LAMVAEDRQI | NDVLEELFAE |
| 790 | 800 | 810 | 820 | 830 | 840 |
| EGNEMHIRQA | DIYLREGEEM | SFYEIMLRAR | QRREILIGYR | LANAERAVIN | PPAKTGRRKW |
| 850 | |||||
| SLKDVFVVIT | EKE |