Q5FWY4

PR
Gene name
mmcm6
Protein name
Maternal DNA replication licensing factor mcm6
Names
Maternal minichromosome maintenance protein 6, mMCM6, xMCM6
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:398071
EC number
3.6.4.12: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

648-727 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for Q5FWY4

Entry ID Method Resolution Chain Position Source
8Q6O EM 314 A 6/E 1-821 PDB
8Q6P EM 353 A 6 1-821 PDB
AF-Q5FWY4-F1 Predicted AlphaFoldDB

No variants for Q5FWY4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5FWY4

No associated diseases with Q5FWY4

6 regional properties for Q5FWY4

Type Name Position InterPro Accession
domain MCM domain 336 - 558 IPR001208
conserved_site Mini-chromosome maintenance, conserved site 457 - 465 IPR018525
domain MCM N-terminal domain 29 - 116 IPR027925
domain MCM OB domain 124 - 253 IPR033762
domain Mcm6, C-terminal winged-helix domain 710 - 818 IPR041024
domain MCM, AAA-lid domain 573 - 658 IPR041562

Functions

Description
EC Number 3.6.4.12 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Nucleus
  • Chromosome
  • Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
chromatin The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
CMG complex A protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication.
MCM complex A hexameric protein complex required for the initiation and regulation of DNA replication.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA helicase activity Unwinding of a DNA helix, driven by ATP hydrolysis.
metal ion binding Binding to a metal ion.

4 GO annotations of biological process

Name Definition
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
DNA replication initiation The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate.
DNA unwinding involved in DNA replication The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication.
regulation of DNA-templated DNA replication initiation Any process that modulates the frequency, rate or extent of initiation of DNA-dependent DNA replication; the process in which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MELGGPAAAG DTDIAGQQLF KDELSDKCQK LFLEFLEECK GKDGSNLYVS AAEELIRPER
70 80 90 100 110 120
NTLAVNFTDI EYYNQQLATT IQEEYYRVYP HLCRAVRSFA RQMGNIPANK EFYIAFSDFP
130 140 150 160 170 180
ARQKIRELSS AKIGTLLRIS GQVVRTHPVH PELVSGTFLC MDCQSIVKDV EQQFRYTQPT
190 200 210 220 230 240
ICKNPVCANR RRFTLDTNKS RFVDFQKVRI QETQAELPRG AIPRSVEIIL RAEAVESAMA
250 260 270 280 290 300
GDRCDFTGTL IVVPDVSALA AGDARMETGA KVTGGEGFNS EGVQGLKALG VRDLSYRLAF
310 320 330 340 350 360
LACYVGATNP RFGGKDLREE DQTAESIKNQ MTVQEWEKVF EMSQDKNLYH NLCTSLFPTI
370 380 390 400 410 420
HGNDEIKRGV LLMLFGGVPK TTMEGTSLRG DINVCIVGDP STSKSQFLKH VEEFSPRAVY
430 440 450 460 470 480
TSGKASSAAG LTAAVVKDEE SHEFVIEAGA LMLADNGVCC IDEFDKMDLK DQVAIHEAME
490 500 510 520 530 540
QQTISITKAG VKATLNARTS ILAAANPVGG RYERSKSLKH NVNLSAPIMS RFDLFFILVD
550 560 570 580 590 600
ECNEVTDYAI ARRIVDLHAR NEESIERVYS IEDIQRYLLF ARQFQPKITK EAEEFIVEQY
610 620 630 640 650 660
RRLRQRDGSG VAKSSWRITV RQLESLIRLS ESMARMHCSD EVQPKHVKEA FRLLSKSIIR
670 680 690 700 710 720
VDTPDVSFDQ GEDEKNIEGE NNGNLNNGEE AMETNQDEPI NEKPSSNAGL KMSFAEYKQI
730 740 750 760 770 780
SNLLVLYMQK MEETEEECHL TTTDLVNWYL KEMEAEIETE TELILKKRLI EKVIHRLIYY
790 800 810 820
DHILIELNKS ELKTMDDTKE TGEDAAEDRI LVVNPNYMLE D