Q5FS52

PR
Gene name
hldE
Protein name
Bifunctional protein HldE
Names
Species
Gluconobacter oxydans (strain 621H) (Gluconobacter suboxydans)
KEGG Pathway
gox:GOX1023
EC number
2.7.1.167: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

166-241 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5FS52

Entry ID Method Resolution Chain Position Source
AF-Q5FS52-F1 Predicted AlphaFoldDB

No variants for Q5FS52

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5FS52

No associated diseases with Q5FS52

4 regional properties for Q5FS52

Type Name Position InterPro Accession
domain Cytidyltransferase-like domain 345 - 441 IPR004821
domain Carbohydrate kinase PfkB 12 - 305 IPR011611
domain RfaE bifunctional protein, domain I 5 - 314 IPR011913
domain RfaE bifunctional protein, domain II 334 - 475 IPR011914

Functions

Description
EC Number 2.7.1.167 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
heptose 7-phosphate kinase activity Catalysis of the reaction: D-alpha,beta-D-heptose-7-phosphate + ATP = D-beta-D-heptose-1,7-bisphosphate + ADP.
heptose-1-phosphate adenylyltransferase activity Catalysis of the reaction: D-beta-D-heptose-1-phosphate + ATP = ADP-D-glycero-D-manno-heptose.
phosphotransferase activity, alcohol group as acceptor Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor).

1 GO annotations of biological process

Name Definition
ADP-L-glycero-beta-D-manno-heptose biosynthetic process The chemical reactions and pathways resulting in the formation of ADP-L-glycero-beta-D-manno-heptose, an ADP-L-glycero-D-manno-heptose having beta-configuration at the anomeric centre of the heptose. ADP-L-glycero-beta-D-manno-heptose (also called ADP-L-beta-D-heptose or ADP-L-glycero-D-manno-heptose) is a nucleotide-sugar precursor of the inner core lipopolysaccharide (LPS) from D-glycero-beta-D-manno-heptose 7-phosphate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIDDFRFGRI TVIGDLLLDQ YISGGVSRIS PEAPVPVVLH DGLRCVPGGA ANVAVNAAAL
70 80 90 100 110 120
GAQVHLVGLV GEDDSAARLK ETLKLWPTIE TDGIVSSPDW TTITKTRVVS GRQQIVRIDV
130 140 150 160 170 180
EKLTPLSETL QQRLVEEACR AIAVSDVLVC SDYAKGVLTD EVLRAIIAAG REKGIPVIVD
190 200 210 220 230 240
PKRHTFEAYA GATLVTPNRI EAQQASGLPA RTDGEVLKVA ETLSGQFGGN VLVTRSEDGM
250 260 270 280 290 300
TLWQHDAKPL HVASRKSEVF DVSGAGDTVV ATVAAVLSAG QTLETAVVIA TAAAALSVSK
310 320 330 340 350 360
FGTATVSREE LSRELLQEMP ETGALVPVEQ AARIVESWHR HGAKVVFTNG CFDLVHPGHV
370 380 390 400 410 420
SLLQAAAREG DRLVVALNTD RSVSRLKGPT RPVQKEEARA RVIGALRSVD LVVLFDEDTP
430 440 450 460 470
LEVIRTLKPD ILVKGADYTE DQVVGADVVK SYGGKVVLVD LVEGQSTTRL VRGMQSAPS