Q5FLW6

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)
KEGG Pathway
lac:LBA0417
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

395-470 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5FLW6

Entry ID Method Resolution Chain Position Source
AF-Q5FLW6-F1 Predicted AlphaFoldDB

No variants for Q5FLW6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5FLW6

No associated diseases with Q5FLW6

4 regional properties for Q5FLW6

Type Name Position InterPro Accession
domain DHHA1 domain 737 - 875 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 656 - 699 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 8 - 559 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 4 - 712 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKKLNSSEFR QMFLDFFKEH GHMIMPSASL IPQDDPTLLW INSGVATMKK YFDGSVVPKN
70 80 90 100 110 120
RRITSSQKSI RTNDIENVGK TARHQTFFEM LGNFSVGDYF RDEAIPWAWE FLTSPKWLGL
130 140 150 160 170 180
PKEKLYCTVY PKDEDSFNVW VKAGMPADHI VKLEDNFWDI GEGPCGPDTE IFYDRGQENN
190 200 210 220 230 240
DVAEDDPENF PGGENARYLE IWNIVFSQYN HLPNGKYVDQ PHKNIDTGMG LERVLSILQD
250 260 270 280 290 300
APTNFETDLF LPIIHATEEM TDGKKYGEND EDTTAFKIIA DHVRAVSFAI ADGALPSNSG
310 320 330 340 350 360
RGYVLRRLIR RADLNGQRLG IKGAFLYKLV PVVGKIMESH YPEIMDQRGF IENVIQNEEE
370 380 390 400 410 420
RFQSTLDTGL TLLDDLIEKA KNSDDKTISG KDAFKMFDTY GFPYELTFES AQDAGLKVDK
430 440 450 460 470 480
KGFDAEMQAQ KDRARKARGD LQSMGRQDVT LMNIKDKSEF EYGVYEEPHA KLIDIVVDDK
490 500 510 520 530 540
LVDKANGEHA TLVFDKTPFY AERGGQVADH GGIYNQDGEL VAKVTDVQHA PNDQNLHFVD
550 560 570 580 590 600
LILPMEKGQE YVLKIDKERR EGLRHSHSAT HLLHAALRQV LGEHTHQAGS LVDPDYLRFD
610 620 630 640 650 660
FTAMEPMTPR ELKSVEELVN QKIWDAIQVK TTITTPEEGE KMGALALFDG KYGDKVRVVQ
670 680 690 700 710 720
MSDFSSEFCG GTHVDNTDQI GIFKITSESA VGAGMRRIEA VTSKKAYEYL ANRSSLLDDI
730 740 750 760 770 780
QEVVKATKPE NIVDKIDSIE NELRDSQKQV EALTKKINQA KAGEIFDNVK QAGDLTVIAA
790 800 810 820 830 840
IADVNGMNDL RELADNWKSG NKSDVLVLAA ENDGKANMII SLDQRALDKG LKAGDLIKKA
850 860 870
APLFGGGGGG RPNMAQAGGK KPEGLNDAIK AVIDEISNN