Q5FKW5

PR
Gene name
valS
Protein name
Valine--tRNA ligase
Names
Valyl-tRNA synthetase, ValRS
Species
Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM)
KEGG Pathway
lac:LBA0794
EC number
6.1.1.9: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-134 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5FKW5

Entry ID Method Resolution Chain Position Source
AF-Q5FKW5-F1 Predicted AlphaFoldDB

No variants for Q5FKW5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5FKW5

No associated diseases with Q5FKW5

5 regional properties for Q5FKW5

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 45 - 56 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 17 - 560 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 605 - 752 IPR013155
domain Valyl-tRNA synthetase, tRNA-binding arm 811 - 876 IPR019499
domain Valyl tRNA synthetase, anticodon-binding domain 560 - 693 IPR033705

Functions

Description
EC Number 6.1.1.9 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
valine-tRNA ligase activity Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+).

1 GO annotations of biological process

Name Definition
valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a valine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTDLAPKYNP NEVEKGRYQE WLDEDLFKPS GDKKAHPYSI VIPPPNVTGK LHLGHAWDTA
70 80 90 100 110 120
IQDTLIRFKR MEGYDTLYLP GMDHAGIATQ AKVEAKLRKQ GKDRHEMGRE AFVKQVWDWK
130 140 150 160 170 180
DEYANIIKSQ WSKLGLSLDY SRERFTLDKG LSKAVKKVFV QLYNEGLIYR GEYIINWDPT
190 200 210 220 230 240
LETALSDIEV IHKDDKGAFY HVKYPFADGS GFVEIATTRP ETMFGDTAVA VAPGDPRYKD
250 260 270 280 290 300
IVGKELILPL VGRHIPIIED QHVDPEFGTG LVKITPAHDP NDFQVGNRHN LKRINVMNDD
310 320 330 340 350 360
GTMNEEAGKY AGMDRFECRE ALVKDLKEEG YLIKVEPIVH SVGHSERSGV QVEPRLSKQW
370 380 390 400 410 420
FVKMKPLADK VLENQKSEGK VNFVPERFEQ TLNHWMENVH DWVISRQLWW GHRIPAWYNK
430 440 450 460 470 480
KTGETYVGEE APKDIENWEQ DPDVLDTWFS SALWPFSTMG WPDTDNPDFK RYFPTNALVT
490 500 510 520 530 540
GYDIIFFWVS RMIFQSLHFT KERPFKDVVL HGLIRDEQGR KMSKSLGNGI DPMDVIDKYG
550 560 570 580 590 600
ADALRWFLLN GTAPGQDTRF SYTKMDAAWN FINKIWNVSR FVIMNLPEDA KPAHMPDTSK
610 620 630 640 650 660
FDLSDKWIFD RLNHTIGEVT RLFGEYQFGE AGREAYNFIW NDFCDWYIEI SKVALNGDDE
670 680 690 700 710 720
ELKARKQENL IWILDQILRL MHPIMPFVTE KLWLSMPHEG KSIMTASYPV THKEFENKTA
730 740 750 760 770 780
DQEMDFLIEV IKAVRNIRME VNAPMSSEID IMIKLDDLNN KHILDENVDY VENFLHPKKL
790 800 810 820 830 840
EVSADIEAPK LAKTAVIPGA QIFVPLTELV NVDEELAKME KEAKRLEDEV ARCEKKLSNK
850 860 870
GFVDHAPEAV VNKEKEKMAD YESQLSGVRE RIQDLKESK