Q5FKL6
Gene name |
thyA |
Protein name |
Thymidylate synthase |
Names |
TS, TSase |
Species |
Lactobacillus acidophilus (strain ATCC 700396 / NCK56 / N2 / NCFM) |
KEGG Pathway |
lac:LBA0901 |
EC number |
2.1.1.45: Methyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5FKL6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5FKL6-F1 | Predicted | AlphaFoldDB |
No variants for Q5FKL6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5FKL6 | |||||
No associated diseases with Q5FKL6
11 regional properties for Q5FKL6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | B-box-type zinc finger | 84 - 125 | IPR000315 |
| domain | Zinc finger, RING-type | 16 - 57 | IPR001841 |
| domain | B30.2/SPRY domain | 275 - 474 | IPR001870 |
| domain | SPRY domain | 345 - 473 | IPR003877 |
| domain | Butyrophylin-like, SPRY domain | 291 - 308 | IPR003879-1 |
| domain | Butyrophylin-like, SPRY domain | 330 - 354 | IPR003879-2 |
| domain | Butyrophylin-like, SPRY domain | 360 - 373 | IPR003879-3 |
| domain | Butyrophylin-like, SPRY domain | 404 - 428 | IPR003879-4 |
| domain | SPRY-associated | 292 - 344 | IPR006574 |
| conserved_site | Zinc finger, RING-type, conserved site | 31 - 40 | IPR017907 |
| domain | Zinc finger, RING-type, eukaryotic | 16 - 54 | IPR027370 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.1.1.45 | Methyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| thymidylate synthase activity | Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| dTMP biosynthetic process | The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate). |
| dTTP biosynthetic process | The chemical reactions and pathways resulting in the formation of dTTP, deoxyribosylthymine triphosphate. |
| methylation | The process in which a methyl group is covalently attached to a molecule. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAILEQPYLD | LINKIMIEGH | DKNDRTGTGT | RSYFGAQMRF | DLSKGFPILT | TKKVPFGLIK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SELLWFLRGD | TNIRFLLEHK | NHIWDEWAFK | NWVNSDEYTG | PDMTDFGLRS | QSDPEFNKIY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QAELKKFDRR | ILDDENFAKK | YGNLGDVYGA | QWRHWQKRDG | SFIDQIENVI | EQIKNNPDSR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RMIVTAWNPE | DVPTSALPPC | HVMFQFYVVD | GKISVQLYQR | SGDMFLGVPF | NIASYALLLN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MIARETGLQV | GEFIHTLGDA | HIYSNHFSQV | KEMLSRKPYE | SPQLWLNPEK | KHIEDFDMQD |
| 310 | |||||
| IKLVDYKHHG | TIKAPVAV |