Q5F7C4

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090)
KEGG Pathway
ngo:NGO_1254
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

392-475 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5F7C4

Entry ID Method Resolution Chain Position Source
AF-Q5F7C4-F1 Predicted AlphaFoldDB

No variants for Q5F7C4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5F7C4

No associated diseases with Q5F7C4

4 regional properties for Q5F7C4

Type Name Position InterPro Accession
domain DHHA1 domain 738 - 869 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 651 - 694 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 5 - 553 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 1 - 707 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKTSELRQKF LKFFETKGHT VVRSSSLVPH DDPTLLFTNA GMNQFKDVFL GFDKRPYSRA
70 80 90 100 110 120
TTAQKCVRAG GKHNDLENVG YTARHHTFFE MMGNFSFGDY FKRDAIHFAW EFLTSPEWLN
130 140 150 160 170 180
IPKDKLLATV YAEDDEAYNI WLNEIGMPSE RIVRIGDNKG AKYASDNFWQ MGDTGPCGPC
190 200 210 220 230 240
SEIFYDHGKE IWGGIPGSPE EDGDRWIEIW NCVFMQFNRD EQGNMNPLPK PSVDTGMGLE
250 260 270 280 290 300
RMAAVMQHVH SNYEIDLFQD LLKAVARETG APFSMEEPSL KVIADHIRSC SFLIADGVLP
310 320 330 340 350 360
SNEGRGYVLR RIIRRAVRHG YKLGQSKPFF HKLVADLVQE MGGAYPELKE KQAQIEEALK
370 380 390 400 410 420
NEESRFAQTL ETGMALLENA LAKGGKTLGG EIIFKLYDTY GFPYDLTADI CRERNIEPDE
430 440 450 460 470 480
AGFEREMEAQ RARARAAQSF KANAQLPYDG QDTEFKGYSE RQTESKVLAL YKDGEQVVEL
490 500 510 520 530 540
NEGDSGAVVI DFTPFYAESG GQVGDVGYIF AGENRFEVRD TQKIKAAVFG QFGVQTSGRL
550 560 570 580 590 600
KVGDSITAKV DDEIRNANMR NHSATHLMHK ALRDVLGGHV EQKGSLVTAE STRFDISHPQ
610 620 630 640 650 660
AVTAEEIAEV ERRVNEAILA NVAVNAAIMS MEDAQKTDAM MLFGEKYGDE VRVLQMGGFS
670 680 690 700 710 720
TELCGGTHVS RTGDIGLFKI ISEGGIAAGV RRIEAITGLN ALKWAQEQER LVKDIIAETK
730 740 750 760 770 780
AQTEKDVLAK IQAGAAHAKA LEKELARAKA ELAVHAGAKL LDDAKDLGAA KLVAAQIEAD
790 800 810 820 830 840
AAALRETVTD LTGKSDNAVI LLAAVNEGKV SLCAGVSKAL TGKVKAGDLV KFAAEQVGGK
850 860 870
GGGRPDLAQA GGTDADKLPE MLASAEGWLC QKLS