Q5F383
Gene name |
SPPL2B |
Protein name |
Signal peptide peptidase-like 2B |
Names |
SPP-like 2B, SPPL2b |
Species |
Gallus gallus (Chicken) |
KEGG Pathway |
gga:420056 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5F383
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5F383-F1 | Predicted | AlphaFoldDB |
No variants for Q5F383
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5F383 | |||||
No associated diseases with Q5F383
1 regional properties for Q5F383
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | PA domain | 81 - 146 | IPR003137 |
Functions
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| endosome membrane | The lipid bilayer surrounding an endosome. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| Golgi-associated vesicle membrane | The lipid bilayer surrounding a vesicle associated with the Golgi apparatus. |
| integral component of cytoplasmic side of endoplasmic reticulum membrane | The component of the endoplasmic reticulum membrane consisting of the gene products that penetrate only the cytoplasmic side of the membrane. |
| integral component of lumenal side of endoplasmic reticulum membrane | The component of the endoplasmic reticulum membrane consisting of the gene products that penetrate only the lumenal side of the membrane. |
| lysosomal membrane | The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| aspartic endopeptidase activity, intramembrane cleaving | Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within a membrane. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| membrane protein ectodomain proteolysis | The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain). |
| membrane protein intracellular domain proteolysis | The proteolytic cleavage of a transmembrane protein leading to the release of an intracellular domain. |
| membrane protein proteolysis | The proteolytic cleavage of a transmembrane protein leading to the release of its intracellular or ecto-domains. |
| regulation of immune response | Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAARWAQFLL | FSLLSLPQVY | CEYGMVHVLS | EKGSSKGKDY | CILFNSQWAH | LPHDLGKASL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LQLQDQTASV | LCSPSDVPDG | GFNNRIPMVM | RGNCTFYEKV | RLAQINGARG | LLIVSRERLV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PPGGNRSQYE | EIDIPVALLS | YSDMLDIVKS | FGRSVKGAMY | APNEPVLDYN | MVIIFVMAVG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TVAIGGYWAG | SRDVKERYMK | HKRDDGAEKH | EDETVDVTPI | MICVFVVMCC | SMLVLLYFFY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DHLVYVIIGI | FCLAASIGLY | SCLSPFVRRF | PLGKCRIPDN | NLPYFHKRPQ | VRILLLAVFC |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ISVSVVWGVF | RNEDQWAWVL | QDALGIAFCL | YMLKTIRLPT | FKGCTLLLLV | LFVYDVFFVF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ITPFLTKTGE | SIMVEVAAGP | SDSATHEKLP | MVLKVPRLNS | SPLALCDRPF | SLLGFGDILV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PGLLVAYCHR | FDIQVQSSRV | YFVACTIAYG | IGLLVTFVAL | ALMQMGQPAL | LYLVPCTLIT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SFSVALWRKE | LAMFWTGSGF | AKDLPQPPLV | IASVNCPQLP | KDSNVPASQQ | ETEEMANPTL |
| 550 | 560 | 570 | 580 | 590 | |
| HVKELHSPTL | AAEEPADNDT | KTEQSEVSIA | QSEEAAGHNK | DDLESKSLNL | EQKQLE |