Q5EAU3

PR
Gene name
pip4p2
Protein name
Type II phosphatidylinositol 4,5-bisphosphate 4-phosphatase
Names
Type 2 PtdIns-4,5-P2 4-Ptase, PtdIns-4,5-P2 4-Ptase II, Transmembrane protein 55A
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:734343
EC number
3.1.3.78: Phosphoric monoester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-77 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5EAU3

Entry ID Method Resolution Chain Position Source
AF-Q5EAU3-F1 Predicted AlphaFoldDB

No variants for Q5EAU3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5EAU3

No associated diseases with Q5EAU3

4 regional properties for Q5EAU3

Type Name Position InterPro Accession
domain Phosphatidylinositol 3-/4-kinase, catalytic domain 523 - 802 IPR000403
domain Phosphoinositide 3-kinase, accessory (PIK) domain 55 - 245 IPR001263
conserved_site Phosphatidylinositol 3/4-kinase, conserved site 551 - 565 IPR018936-1
conserved_site Phosphatidylinositol 3/4-kinase, conserved site 644 - 664 IPR018936-2

Functions

Description
EC Number 3.1.3.78 Phosphoric monoester hydrolases
Subcellular Localization
  • Late endosome membrane ; Multi-pass membrane protein
  • Lysosome membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
late endosome membrane The lipid bilayer surrounding a late endosome.
lysosomal membrane The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.

1 GO annotations of molecular function

Name Definition
phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity Catalysis of the reaction: 1-phosphatidyl-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate.

1 GO annotations of biological process

Name Definition
phosphatidylinositol dephosphorylation The process of removing one or more phosphate groups from a phosphatidylinositol.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAADGIDERS PLISPSSGNV TPTAPPYIQE NNLQAELPPP YTAIASPDAG GVPVINCRVC
70 80 90 100 110 120
QSLINLDGKL HQHVVKCTVC NEATPIKTPP LGKKYVRCPC NCLLICKDIS RRIGCPRPNC
130 140 150 160 170 180
RRIINLGPVM LIPEEQPAQP ALPVQPDGTR VVCGHCGNTF LWMELRFNTL AKCPHCKKIS
190 200 210 220 230 240
SVGSALPRRR CCTYITMGMI CIFIGVGLTV GTQDFARRFH ATYVSWAVAY LVGLVCLVRA
250
CYWGAIKFSY PEHSFA