Q5E9U4
Gene name |
TYW3 |
Protein name |
tRNA wybutosine-synthesizing protein 3 homolog |
Names |
tRNA-yW-synthesizing protein 3, tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:519731 |
EC number |
2.1.1.282: Methyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5E9U4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5E9U4-F1 | Predicted | AlphaFoldDB |
23 variants for Q5E9U4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs479489083 | 11 | K>Q | No | EVA | |
| rs207894131 | 12 | A>V | No | EVA | |
| rs446007579 | 16 | S>I | No | EVA | |
| rs477188162 | 19 | D>A | No | EVA | |
| rs463509134 | 19 | D>E | No | EVA | |
| rs443447343 | 36 | L>P | No | EVA | |
| rs475921031 | 45 | T>A | No | EVA | |
| rs475921031 | 45 | T>S | No | EVA | |
| rs462232721 | 50 | A>S | No | EVA | |
| rs441989921 | 52 | R>G | No | EVA | |
| rs473415251 | 55 | L>I | No | EVA | |
| rs43346598 | 58 | R>G | No | EVA | |
| rs481744185 | 61 | N>T | No | EVA | |
| rs441373151 | 71 | C>* | No | EVA | |
| rs441373151 | 71 | C>W | No | EVA | |
| rs435816189 | 87 | V>G | No | EVA | |
| rs463265472 | 90 | Q>H | No | EVA | |
| rs439185767 | 100 | F>Y | No | EVA | |
| rs516264742 | 104 | V>I | No | EVA | |
| rs446546570 | 114 | D>H | No | EVA | |
| rs383709598 | 223 | P>L | No | EVA | |
| rs435985546 | 230 | R>H | No | EVA | |
| rs720606553 | 248 | G>R | No | EVA |
No associated diseases with Q5E9U4
1 regional properties for Q5E9U4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | tRNA wybutosine-synthesizing protein | 11 - 193 | IPR003827 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.1.1.282 | Methyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| tRNA methyltransferase activity | Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| tRNA methylation | The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDLSAEFKRW | KAQCLSKADL | SRKGSVDEDV | LEIVQLLNGQ | EQFFTTSSCA | GRIILLDRSV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NGSEVQKQNC | CWLLVTHKAC | VKDDVIVALQ | KAKGDAILKF | EPLVLHVQCR | QLQDAQILHS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VAIDSGFRNS | GITVGKRGKT | MLAVRSTHGL | EVPLSHQGKL | MVTEEYINFL | LKIANQKMEE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NKKRIERFYH | CLQHALEKET | VSTTSQPKEK | VNTSYIRKKK | RNPGKARGKR | VNEEHDKELE |
| 250 | |||||
| NNDHDDPGIS | DTIFPEDY |