Q5DTN8

PR
Gene name
Jakmip3 (Kiaa4091, Necc2)
Protein name
Janus kinase and microtubule-interacting protein 3
Names
Neuroendocrine long coiled-coil protein 2
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:74004
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

349-418 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5DTN8

Entry ID Method Resolution Chain Position Source
AF-Q5DTN8-F1 Predicted AlphaFoldDB

24 variants for Q5DTN8

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388936192 6 A>T No EVA
rs3388955495 41 Q>E No EVA
rs3388936172 46 V>D No EVA
rs3388938187 93 A>E No EVA
rs3388959101 100 A>T No EVA
rs3398701300 114 Q>R No EVA
rs3388959387 123 L>Q No EVA
rs3388950283 126 G>V No EVA
rs218468518 184 A>S No EVA
rs3388951645 200 I>T No EVA
rs3388944831 211 L>P No EVA
rs31951601 216 R>K No EVA
rs3388955496 261 G>D No EVA
rs3388951656 279 H>N No EVA
rs3388951608 308 K>M No EVA
rs3388912916 320 R>T No EVA
rs3388962664 351 L>M No EVA
rs3388962649 353 H>L No EVA
rs3388959117 374 Q>R No EVA
rs3388944874 409 N>Y No EVA
rs3388955469 415 S>F No EVA
rs3388940359 480 Q>K No EVA
rs3388955466 484 T>N No EVA
rs52071641 634 D>E No EVA

No associated diseases with Q5DTN8

1 regional properties for Q5DTN8

Type Name Position InterPro Accession
domain Janus kinase and microtubule-interacting protein, C-terminal domain 429 - 626 IPR031994

Functions

Description
EC Number
Subcellular Localization
  • Golgi apparatus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.

2 GO annotations of molecular function

Name Definition
kinase binding Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group.
microtubule binding Binding to a microtubule, a filament composed of tubulin monomers.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5VZ66 JAKMIP3 Janus kinase and microtubule-interacting protein 3 Homo sapiens (Human) PR
10 20 30 40 50 60
MSKKGAGSRA KGDKAETLAA LQAANEELRA KLTDIQIELQ QEKSKVSKVE REKSQELKQV
70 80 90 100 110 120
REHEQRKHAV LVTELKTKLH EEKMKELQAV REALLRQHEA ELLRVIKIKD NENQRLQALL
130 140 150 160 170 180
NTLRDGAPDK VKTVLLCEAK EEAKKGFEVE KVKMQQEISE LKGAKKQVEE ALTMVIQADK
190 200 210 220 230 240
IKAAEIRSVY HLHQEEITRI KKECEREIRR LMEEIRFKDR AVFVLERELG VQAGHAQRLQ
250 260 270 280 290 300
LQKEALDEQL SQAKEAERHP GSPRRELPYA SGAGDASDHS GSPEQQLDEK DARRFQLKIA
310 320 330 340 350 360
ELSAIIRKLE DRNALLSEER NELLKRLREA ESQYKPLLDK NKRLTRKNED LSHTLRRIES
370 380 390 400 410 420
KLKFVTQENI EMRQRAGIIR RPSSLNDLDQ SQDEREIDFL KLQIVEQQNL IDELSKTLET
430 440 450 460 470 480
AGYVKSVLER DKLLRYRKQR KKMAKLPKPV VVETFFGYDE EASLESDGSS ISYQTDRTDQ
490 500 510 520 530 540
TPCTPEDDLE EGMAKEETEL RFRQLTMEYQ ALQRAYALLQ EQVGGTLDAE REVKTREQLQ
550 560 570 580 590 600
AEIQRAQTRV EDLEKALAEQ GQDMKWIEEK QALYRRNQEL VEKIKQMETE EARLKHEVQD
610 620 630 640 650 660
AKDQNELLEF RILELEERER KSPAINFHHT PFVDGKSPLQ VYCEAEGVTD ILVTELMKKL
670 680 690 700 710 720
DILGDNANLT NEEQVVVIQA RTVLTLAEKW LQRIEETESA LQRKMVDLES EKELFSKQKG
730 740 750 760 770 780
YLDEELDYRK QALDQAHKHI LELEAMLYDA LQQEAGAKVA ELLSEEEREK LKVAVEQWKR
790 800 810 820 830 840
QVMSELRERD AQILRERMEL LQIAQQRIKE LEERIETQKR QIKELEEKFL FLFLFFSLAF
ILWS