Q5D7I2

PR
Gene name
TRIM5
Protein name
Tripartite motif-containing protein 5
Names
RING-type E3 ubiquitin transferase TRIM5, TRIM5alpha
Species
Pithecia pithecia (White-faced saki)
KEGG Pathway
EC number
2.3.2.27: Aminoacyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

119-289 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5D7I2

Entry ID Method Resolution Chain Position Source
AF-Q5D7I2-F1 Predicted AlphaFoldDB

No variants for Q5D7I2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5D7I2

No associated diseases with Q5D7I2

9 regional properties for Q5D7I2

Type Name Position InterPro Accession
domain B-box-type zinc finger 91 - 132 IPR000315
domain Zinc finger, RING-type 15 - 59 IPR001841
domain B30.2/SPRY domain 280 - 494 IPR001870
domain SPRY domain 348 - 493 IPR003877
domain Butyrophylin-like, SPRY domain 314 - 331 IPR003879-1
domain Butyrophylin-like, SPRY domain 430 - 454 IPR003879-2
domain Butyrophylin-like, SPRY domain 462 - 480 IPR003879-3
conserved_site Zinc finger, RING-type, conserved site 30 - 39 IPR017907
domain Zinc finger, RING-type, eukaryotic 15 - 56 IPR027370

Functions

Description
EC Number 2.3.2.27 Aminoacyltransferases
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Predominantly localizes in cytoplasmic bodies
  • Localization may be influenced by the coexpression of other TRIM proteins, hence partial nuclear localization is observed in the presence of TRIM22 or TRIM27
  • In cytoplasmic bodies, colocalizes with proteasomal subunits and SQSTM1
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
P-body A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.

3 GO annotations of molecular function

Name Definition
pattern recognition receptor activity Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species to initiate an innate immune response.
ubiquitin-protein transferase activity Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
zinc ion binding Binding to a zinc ion (Zn).

9 GO annotations of biological process

Name Definition
activation of innate immune response Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species.
autophagy The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
defense response to virus Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
positive regulation of I-kappaB kinase/NF-kappaB signaling Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
positive regulation of MAPK cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
positive regulation of NF-kappaB transcription factor activity Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
protein K63-linked ubiquitination A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair.
regulation of lipopolysaccharide-mediated signaling pathway Any process that modulates the frequency, rate or extent of signaling in response to detection of lipopolysaccharide.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MASRILMNIK EEVTCPICLE LLTEPLSLDC GHSFCQACIT ANHKKSMLHQ GERSCPLCRI
70 80 90 100 110 120
SYPSENLRPN RHLANIVERL REVMLSPEEG QKVDHCARHG EKLLLFCQQD GNVICWLCER
130 140 150 160 170 180
SQEHRGHHTL LVEEVAQTYR ENLQVALETM RQKQQDAEKL EADVREEQAS WKIQIRDDKT
190 200 210 220 230 240
NIMAEFKQLR DILDCEESNE LQILEKEEKN ILKRLTQSEN DMVLQTQSMG VLISDLEHRL
250 260 270 280 290 300
QGSVMELLQG VDEVIKRVKN VTLQKPKTFL NEKRRVFRAP DLKGMLQVFK ELTEVQRYWV
310 320 330 340 350 360
HVTLVPSHLS CAVISEDERQ VRYQERIHQS FGKVKYFYGV LGSPSIRSGK HYWEVDVSNK
370 380 390 400 410 420
SAWILGVCVS LKCTANRNGP RIENYQPKNG YWVIGLWNAG NYSAFQDSVK YSDFQDGSHS
430 440 450 460 470 480
ATYGPLIVPL FMTICPNRVG VFLDYEACTV SFFNVTSNGF LIYKFSNCRF SDSVFPYFSP
490
MTCELPMTLC SPRS