Q5BK46
Gene name |
Rnaseh1 |
Protein name |
Ribonuclease H1 |
Names |
RNase H1 |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:298933 |
EC number |
3.1.26.4: Endoribonucleases producing 5'-phosphomonoesters |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5BK46
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5BK46-F1 | Predicted | AlphaFoldDB |
No variants for Q5BK46
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5BK46 | |||||
No associated diseases with Q5BK46
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.26.4 | Endoribonucleases producing 5'-phosphomonoesters |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| identical protein binding | Binding to an identical protein or proteins. |
| magnesium ion binding | Binding to a magnesium (Mg) ion. |
| nucleic acid binding | Binding to a nucleic acid. |
| RNA-DNA hybrid ribonuclease activity | Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA replication, removal of RNA primer | Removal of the Okazaki RNA primer from the lagging strand of replicating DNA, by a combination of the actions of DNA polymerase, DNA helicase and an endonuclease. |
| mitochondrial DNA replication | The process in which new strands of DNA are synthesized in the mitochondrion. |
| RNA phosphodiester bond hydrolysis, endonucleolytic | The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O70338 | Rnaseh1 | Ribonuclease H1 | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRWLLPLFRT | VTLAVVRVRR | GVCGLGMFYA | VRRGRRTGVF | LSWSECKAQV | DRFPAARFKK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FATEDEAWAF | VRSSSSPDGS | KGQESAHVQK | LQVKTSKRPR | EPLGEEEEPP | EPGAKHTRQD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TEPAALVSKD | AFSYMGESVV | VYTDGCCSSN | GRKRARAGIG | VYWGPGHPLN | VGIRLPGRQT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NQRAEIHAAC | KAITQAKAQN | ISKLVLYTDS | MFTINGITNW | VQGWKKNGWR | TSTGKDVINK |
| 250 | 260 | 270 | 280 | ||
| EDFMELDELT | QGMDIQWMHI | PGHSGFVGNE | EADRLAREGA | KQSEG |