Q5BBL3

PR
Gene name
ste20 (AN2067)
Protein name
Serine/threonine-protein kinase ste20
Names
Species
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
KEGG Pathway
ani:AN2067.2
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

147-246 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

703-726 (Activation loop from InterPro)

Target domain

567-818 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q5BBL3

Entry ID Method Resolution Chain Position Source
AF-Q5BBL3-F1 Predicted AlphaFoldDB

No variants for Q5BBL3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5BBL3

No associated diseases with Q5BBL3

5 regional properties for Q5BBL3

Type Name Position InterPro Accession
domain CRIB domain 238 - 295 IPR000095
domain Protein kinase domain 567 - 818 IPR000719
active_site Serine/threonine-protein kinase, active site 682 - 694 IPR008271
binding_site Protein kinase, ATP binding site 573 - 596 IPR017441
domain p21 activated kinase binding domain 239 - 282 IPR033923

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
incipient cellular bud site The portion of the budding yeast plasma membrane where a daughter cell will emerge. The yeast marks this spot with bud-site selection proteins before bud emergence occurs. Actin is polarized to this spot just prior to and during bud emergence.
mating projection tip The apex of the mating projection in unicellular fungi exposed to mating pheromone; site of polarized growth.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
enzyme binding Binding to an enzyme, a protein with catalytic activity.
histone kinase activity (H2B-S14 specific) Catalysis of the transfer of a phosphate group to the serine-14 or an equivalent residue of the N-terminal tail of histone H2B.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

17 GO annotations of biological process

Name Definition
bipolar cellular bud site selection The process of defining subsequent sites of bud emergence such that budding takes place at alternating poles of a budding cell.
budding cell apical bud growth Growth at the tip of a bud, in a cell that reproduces by budding.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
invasive growth in response to glucose limitation A growth pattern exhibited by budding haploid cells under certain growth conditions, in which cells retain the typical axial budding pattern of haploids, but become elongated and fail to separate after division; during growth on a solid substrate, this results in penetration of cells into the agar medium. An example of this process is found in Saccharomyces cerevisiae.
negative regulation of gene expression Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
osmosensory signaling pathway via Sho1 osmosensor The series of molecular signals generated in response to osmotic change, as mediated through a Sho1 osmosensor system.
pheromone-dependent signal transduction involved in conjugation with cellular fusion A signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae.
positive regulation of apoptotic process Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
protein phosphorylation The process of introducing a phosphate group on to a protein.
pseudohyphal growth The process in which cells grow as a chain of physically attached, elongated cells in response to an environmental stimulus or stimuli.
regulation of exit from mitosis Any process involved in the progression from anaphase/telophase to G1 that is associated with a conversion from high to low mitotic CDK activity.
regulation of MAPK cascade Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade.
signal transduction involved in filamentous growth Relaying of environmental signals promoting filamentous growth.
sterol import The directed movement of a sterol into a cell or organelle. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
stress granule assembly The aggregation, arrangement and bonding together of proteins and RNA molecules to form a stress granule.
vacuole inheritance The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNNDSFSSFK FRRPSSKLHK DPPGYGSRAL NSQQSTTSLK RHPSAPVYPR SSAAGSREHL
70 80 90 100 110 120
RTRSNAYGSS SSSLDQNSAG ASPVLGSSDS GHFHSSHSSR SRPPYSGRFS LNDQSSDELI
130 140 150 160 170 180
GAPFDSRGML SALEEHTAEP DNRSYQPPDP AERYTEKPPN FRSQTTPNPR ALRQSASFTT
190 200 210 220 230 240
LPPRMEAFPN AAGNDRPTNT KRFSDEATPV RPPGPSRSKK SSFSSFVNSM LGSPRGIKIS
250 260 270 280 290 300
APENPVHVTH VGYDNQTGQF TGLPKEWQRL LQESGITQKE QEEHPQTMVD IMRFYEKNAR
310 320 330 340 350 360
GDDEVWHKFD HAYPQQPTAA SPISQPAGST TYGTQRTSPP TSPRFPQNHE GSFENPRAPP
370 380 390 400 410 420
PIPRAAPIAA HAMSPPLGGL VPNRAPPKPP TAAANLVPSR PAPQPPTSSP YSNISTRPSP
430 440 450 460 470 480
ETQSPQFSTP PIPETEPLPS ESQRSRSNSR TNGAQGPWPS VSPSHYQQQQ EQAMAVAQQA
490 500 510 520 530 540
LANKQLERSR SQRQQQQSPR PDQMPIAQPA LPQHAPSPED VALTQASQTA RAAPAARPRQ
550 560 570 580 590 600
RPRQSNAMDV RARLVAICTP GDPTKLYYNL NKIGQGASGG VFTAYEQHTN NCVAIKQMNL
610 620 630 640 650 660
DLQPKKDLII NEILVMKDSK HKNIVNFLDS YLHGLDLWVV MEYMEGGSLT DVVTFNIMSE
670 680 690 700 710 720
PQIAAVCRET LNGLQHLHSK GVIHRDIKSD NILLSLDGNI KLTDFGFCAQ INDSQNKRNT
730 740 750 760 770 780
MVGTPYWMAP EVVTRKEYGR KVDIWSLGIM AIEMIEGEPP YLTESPLRAL YLIATNGTPK
790 800 810 820 830 840
IKDEHNLSPV FKDFLHFALR VDPEKRASAH DLLKHPFMNL CAPLNHLSPL VKAARISRAQ
EKAQKGGV