Q5BBF1

PR
Gene name
rri1 (csn5, csnE, AN2129)
Protein name
COP9 signalosome complex subunit 5
Names
Species
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
KEGG Pathway
ani:AN2129.2
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

231-333 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5BBF1

Entry ID Method Resolution Chain Position Source
AF-Q5BBF1-F1 Predicted AlphaFoldDB

No variants for Q5BBF1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5BBF1

No associated diseases with Q5BBF1

No regional properties for Q5BBF1

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q5BBF1

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
COP9 signalosome A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
deNEDDylase activity An isopeptidase activity that cleaves NEDD8 from a target protein to which it is conjugated.
metal ion binding Binding to a metal ion.
metalloendopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
metallopeptidase activity Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

4 GO annotations of biological process

Name Definition
cleistothecium development The process whose specific outcome is the progression of the cleistothecium over time, from its formation to the mature structure. The cleistothecium is a closed sexual fruiting body that contains ascospores in linear asci, characteristic of some filamentous Ascomycete fungi such as members of the genera Aspergillus and Emericella.
hyphal growth Growth of fungi as threadlike, tubular structures that may contain multiple nuclei and may or may not be divided internally by septa, or cross-walls.
protein deneddylation The removal of a ubiquitin-like protein of the NEDD8 type from a protein.
protein neddylation Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQAAQLSWEL ENAVTLIDPQ RDSLYRYDEE THKYLSDTRP WTKDPHYFKS VRISAVALLK
70 80 90 100 110 120
MVMHARSGGS LEVMGLMQGY ILPNTFVVTD AFRLPVEGTE TRVNAQDEAN EYMVSYLQSC
130 140 150 160 170 180
REAGRMENAV GWYHSHPGYG CWLSGIDVST QDMQQMSGPF VAVVIDPERT ISAGKVDIGA
190 200 210 220 230 240
FRTFPKDYTP PKEEQEEDEY QTVPLNKAED FGAHASHYYS LEVSLFKSAL DTEILSLLWN
250 260 270 280 290 300
KYWVATLSQS PLFTTRDYGS KQMLDLSQKT RRVARGIESN PPRGGAPTQV RDQQLERVVK
310 320 330
DGQRIVSEEV KGLLAAEVKM QLFQGIGGKQ TVEST