Q5BBA8

PR
Gene name
ssn8 (AN2172)
Protein name
RNA polymerase II holoenzyme cyclin-like subunit
Names
Species
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
KEGG Pathway
ani:AN2172.2
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-69 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5BBA8

Entry ID Method Resolution Chain Position Source
AF-Q5BBA8-F1 Predicted AlphaFoldDB

No variants for Q5BBA8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5BBA8

No associated diseases with Q5BBA8

4 regional properties for Q5BBA8

Type Name Position InterPro Accession
domain Signal recognition particle, SRP54 subunit, GTPase domain 100 - 295 IPR000897
domain AAA+ ATPase domain 99 - 273 IPR003593
domain Signal recognition particle, SRP54 subunit, M-domain 327 - 425 IPR004125
domain Signal recognition particle SRP54, helical bundle 2 - 87 IPR013822

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
mediator complex A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name Definition
cyclin-dependent protein serine/threonine kinase regulator activity Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins.

2 GO annotations of biological process

Name Definition
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAANYWASTQ RKHWLFTRER LAEIRESFKE KDKASHTHFP LPDQRLLNIY FNQQLIKLGK
70 80 90 100 110 120
RMSTRQQALA TAQVYIKRYY TKNEIRNTNP YLVLTTAFYL ACKMEECPQH IRFVVSEARA
130 140 150 160 170 180
LWPEFIVPDV SKVGECEFSL ISEMQAQLIV HHPYRTLSEL QPELSLTSDE VALAWSVIND
190 200 210 220 230 240
HYLTDLSLLY PPHIIAVMAI IVAVVFKPSS QTAFHGSAAP IAGAMRDGGM NILAALSDKG
250 260 270 280 290 300
GAGPPPRIQK LIAWLAESEV DIKAVIESTQ ELVSLYEVWE QYSEKNCKEL LGRMIRSKSL
DK