Q5B4P0

PR
Gene name
tim50 (AN4490)
Protein name
Mitochondrial import inner membrane translocase subunit tim50
Names
Species
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
KEGG Pathway
ani:AN4490.2
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-199 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5B4P0

Entry ID Method Resolution Chain Position Source
AF-Q5B4P0-F1 Predicted AlphaFoldDB

No variants for Q5B4P0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5B4P0

No associated diseases with Q5B4P0

3 regional properties for Q5B4P0

Type Name Position InterPro Accession
domain FKBP-type peptidyl-prolyl cis-trans isomerase domain 159 - 249 IPR001179
domain Trigger factor, C-terminal 264 - 425 IPR008880
domain Trigger factor, ribosome-binding, bacterial 1 - 145 IPR008881

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion inner membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
TIM23 mitochondrial import inner membrane translocase complex The protein transport machinery of the mitochondrial inner membrane that typically transports proteins that possess a matrix-targeting N-terminal presequence. The TIM23 complex contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor.

3 GO annotations of molecular function

Name Definition
identical protein binding Binding to an identical protein or proteins.
mitochondrion targeting sequence binding Binding to a mitochondrion targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the mitochondrion.
protein transmembrane transporter activity Enables the transfer of a protein from one side of a membrane to the other.

2 GO annotations of biological process

Name Definition
protein import into mitochondrial matrix The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together.
regulation of mitochondrial membrane permeability Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLRRAILPLT RPSGLVSAPR LSALPVSHSR CYAKGSKPKT PYKLPESVKS SKPEQPAKPS
70 80 90 100 110 120
QQEQYAAEQA EFETTSDPQA NTANTTSQAS SSPESSPSQS EQDAPQRPLP DLTQGIPSTL
130 140 150 160 170 180
AAELEARSKK SGSGTLNLTE DPSRFEEDYS DDGRGDIPKG GYESSLDRKR ARMAKLMYAL
190 200 210 220 230 240
FLLGSVGGMA YLGRNWDTVE EENAHPDVPS GWSFGLWYNR IKARMGDFTS YYKDPAFPKL
250 260 270 280 290 300
LPDEDPNLRQ PYTLVLSLED LLVHSEWSRE HGWRVAKRPG VDYFLRYLNQ YYELVLFTSV
310 320 330 340 350 360
PSMMADQVLR KLDPYRIIRW PLFREATRYK DGEYIKDLSY LNRDLSKVIL IDTKEEHARL
370 380 390 400 410 420
QPENAIILDK WNGNPKDKTL VALIPFLEYL AGMGVDDVRT VLKSFEGQSI PIEFAKREKA
430 440 450 460 470 480
MRERFEKELA EEQKKRPRSG MGSLASALGL KSSARTLDGE QLPSAGLQEG KMLWDQIRER
490 500 510 520 530
GQKNYELIEK EIRENGEKWL AEMAAEEEKL RQEQMESMKG SLTGFFGGGK KE