Q5B187

PR
Gene name
pam16 (tim16, AN5693)
Protein name
Mitochondrial import inner membrane translocase subunit tim16
Names
Presequence translocated-associated motor subunit pam16
Species
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
KEGG Pathway
ani:AN5693.2
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

2-75 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5B187

Entry ID Method Resolution Chain Position Source
AF-Q5B187-F1 Predicted AlphaFoldDB

No variants for Q5B187

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5B187

No associated diseases with Q5B187

No regional properties for Q5B187

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q5B187

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion inner membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
PAM complex, Tim23 associated import motor Protein complex located on the matrix side of the mitochondrial inner membrane and associated with the TIM23 mitochondrial import inner membrane translocase complex (GO:0005744); ATPase motor activity to drive import of proteins into the mitochondrial matrix.
TIM23 mitochondrial import inner membrane translocase complex The protein transport machinery of the mitochondrial inner membrane that typically transports proteins that possess a matrix-targeting N-terminal presequence. The TIM23 complex contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor.

1 GO annotations of molecular function

Name Definition
protein domain specific binding Binding to a specific domain of a protein.

1 GO annotations of biological process

Name Definition
protein import into mitochondrial matrix The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAHRIVTQVV VTGARVFGRA FAEAYKQASA ASKYQQKTGK SAGGSSSSGI TLDEACKILN
70 80 90 100 110 120
VKPPQAGETN LEQVMERFKK LFDLNDPQKG GSFYLQSKIL RARERIEAEV REAERKAAHE
130
KELKEGWKPK VYKDR