Q5B0W8

PR
Gene name
AN5812
Protein name
Leucine aminopeptidase 2
Names
Epoxide hydrolase, Leukotriene A-4 hydrolase homolog, LTA-4 hydrolase
Species
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
KEGG Pathway
ani:AN5812.2
EC number
3.3.2.10: Ether hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

143-216 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5B0W8

Entry ID Method Resolution Chain Position Source
AF-Q5B0W8-F1 Predicted AlphaFoldDB

No variants for Q5B0W8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5B0W8

No associated diseases with Q5B0W8

No regional properties for Q5B0W8

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q5B0W8

Functions

Description
EC Number 3.3.2.10 Ether hydrolases
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
aminopeptidase activity Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain.
epoxide hydrolase activity Catalysis of the reaction: an epoxide + H2O = a glycol.
metallopeptidase activity Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
zinc ion binding Binding to a zinc ion (Zn).

2 GO annotations of biological process

Name Definition
peptide catabolic process The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MATLMNPVRD PNTLSNYNNW LCTHTTANFE IFFEEKKLVG NVVHKLRSIT NAETDEIILD
70 80 90 100 110 120
SHHVDIRNVQ VAGLPVKAWE LLPPLGPYGT ALKIKLENPV GLNEIIDVDI AVQTTKECTA
130 140 150 160 170 180
LQWLTPAQTS NKKHPYMFSQ CQAIHARSIF PCQDTPDVKC TFDFNITSPL PVIASGLPVR
190 200 210 220 230 240
STSTVPQSGV KTLHRFHQKV PIPSYLFALA SGDIAEAAIG PRSVVATSPD KLEECKWELE
250 260 270 280 290 300
ADTERFIKTI EEIIYPYAWG EYNVLILPPS FPYGGMENPV FTFATPSIIS KDRENVDVIA
310 320 330 340 350 360
HELAHSWSGN LVTSASWEHF WLNEGWTVYL ERRILASLHG EKYRHFSAII GWKALRDSVE
370 380 390 400 410 420
HYSHDHEFTK LVPNLKGEDP DDAFSTIPYE KGFNFLFHLE NLVGKEKFDR FIPHYFTTFK
430 440 450 460 470 480
GKSLDSYDFK ATLLDFFKSD AEASRLLQEL DWDSWFYKPG LPPKPEFDTS LADVVYELAG
490 500 510 520 530 540
KWRSLPESPF QPQPSDIQGL TANQIVVFLE QILLFERPLT AELSKLMGEV YGLTGSENIE
550 560 570 580 590 600
VANLYLQVGL KAADKSVIGP TTDLLGRIGR MKFVRPLYRA LQKVDRQVAI DTFEKHKDFY
610
HPICRGMVEK DLFGKKDA