Q5ASK8

PR
Gene name
sub2 (AN8722)
Protein name
ATP-dependent RNA helicase sub2
Names
Species
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
KEGG Pathway
ani:AN8722.2
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-86 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5ASK8

Entry ID Method Resolution Chain Position Source
AF-Q5ASK8-F1 Predicted AlphaFoldDB

No variants for Q5ASK8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5ASK8

No associated diseases with Q5ASK8

5 regional properties for Q5ASK8

Type Name Position InterPro Accession
domain SH2 domain 580 - 674 IPR000980
domain STAT transcription factor, protein interaction 2 - 122 IPR013799
domain STAT transcription factor, all-alpha domain 145 - 312 IPR013800
domain STAT transcription factor, DNA-binding 326 - 464 IPR013801
domain STAT3, SH2 domain 554 - 715 IPR035855

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
spliceosomal complex Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

2 GO annotations of biological process

Name Definition
mRNA export from nucleus The directed movement of mRNA from the nucleus to the cytoplasm.
mRNA splicing, via spliceosome The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSHEEDLIDY SDEELQTTDA AATTATPAAN GGQAKKDGEL TVTGGRADKK GSYVGIHSTG
70 80 90 100 110 120
FRDFLLKGEL LRAITDCGFE HPSEVQQVCI PTAILNVDVL CQAKSGLGKT AVFVLTTLHQ
130 140 150 160 170 180
LEPVPGECSV LVMCHTRELA YQIKNEYARF SKYLPDVKTA VFYGGTPIQK DIEVLSNKDT
190 200 210 220 230 240
FPNIIVGTPG RLNALVRDKK LSLRNVKAFV LDECDKMLDQ IDMRRDVQEI FRATPTDKQV
250 260 270 280 290 300
MMFSATLSQD VRPICKKFMR NPLEVYVDDD TKLTLHGLQQ YYIKLSEAEK NRKLNELLDS
310 320 330 340 350 360
LEFNQVIIFV KSTIRANELD KLLRECNFPS IAVHSGRYKE FKEFNKRICV ATDVFGRGID
370 380 390 400 410 420
IERINLAINY DLPADADSYL HRVGRAGRFG TKGLSISFVS TPEDEQVLKD IEKRFEVALP
430
EYPEEGVDSS TYMA