Q5APK0

PR
Gene name
PAN2
Protein name
PAN2-PAN3 deadenylation complex catalytic subunit PAN2
Names
PAB1P-dependent poly(A)-specific ribonuclease, Poly(A)-nuclease deadenylation complex subunit 2, PAN deadenylation complex subunit 2
Species
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
KEGG Pathway
cal:CAALFM_C109070WA
EC number
3.1.13.4: Exoribonucleases producing 5'-phosphomonoesters
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

82-151 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5APK0

Entry ID Method Resolution Chain Position Source
AF-Q5APK0-F1 Predicted AlphaFoldDB

No variants for Q5APK0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5APK0

No associated diseases with Q5APK0

3 regional properties for Q5APK0

Type Name Position InterPro Accession
domain Exonuclease, RNase T/DNA polymerase III 986 - 1167 IPR013520
domain PAN2, UCH domain 545 - 898 IPR028881
domain Ubiquitin specific protease domain 544 - 924 IPR028889

Functions

Description
EC Number 3.1.13.4 Exoribonucleases producing 5'-phosphomonoesters
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
P-body A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.
PAN complex A complex that possesses poly(A)-specific ribonuclease activity; catalyzes the message-specific shortening of mRNA poly(A) tails. Contains at least two subunits, known as Pan2p and Pan3p in Saccharomyces.

3 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
nucleic acid binding Binding to a nucleic acid.
poly(A)-specific ribonuclease activity Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP.

3 GO annotations of biological process

Name Definition
mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
nuclear-transcribed mRNA poly(A) tail shortening Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length.
postreplication repair The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication. Includes pathways that remove replication-blocking lesions in conjunction with DNA replication.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDGWSEVLRI PSSVFATDNY NNPTTIVNIT SLQFDSVQNF IWCGDSRGYT RSFTGSFATN
70 80 90 100 110 120
SLYGNLQLYP YTKFHTSDVN YNNPIKQILS HREGILSLSN NAISFNSRRG LSKLQVTSKT
130 140 150 160 170 180
FNNNATTENK FNNLQAMTFN CNSFNDVVVG TDTSMMKFDL NKPNVLSSFD HQGGISLLNN
190 200 210 220 230 240
LGKFLTIANS NGSLDIFDPV SNSTMKTFSA HNGFISNLDV RGNYIATCGY SIKPKRYYHN
250 260 270 280 290 300
QPAEYIVDPL VNIYDTRIMR AIAPVPFPAG AASVKFHPKL PNIIIIASTS GQMQFVDIFD
310 320 330 340 350 360
QTNVYLYQAD LAIPTTTTTT INNKPRMSNL EISENGDFLV FNDNCDNMHL WSISPSSKDF
370 380 390 400 410 420
VNFPQPVEQP DIIDSNFEII DIDANVPLSI VGMPYYKELL LSNYPNDLRF VKETAKLPEP
430 440 450 460 470 480
IDIELILENE TRNNGTKKFF PYDKLKYGPG NVYKPYQSLK DNKENKEISI PKFISERSTT
490 500 510 520 530 540
TTTTTKELKA DNDGKFIDDS IFQYKFQGKL NKVPNCYSRL QIQYSKFGIK DFDFSYYNKT
550 560 570 580 590 600
KECCGLENHT DNSYINSLLQ LYRFQSSIYN QVVGSLSKEW LPNDITTIIT TNNPEGSSIL
610 620 630 640 650 660
NELGYLFDMM FKAQSNNVKI YNLSQVLNHH PNAQKLLNNN ELLNLNSQQV RDLVIEFNNF
670 680 690 700 710 720
LLTTLHQDFQ TQFQENFNLT ELKYEIEIKG NGTSCPMYDK HQGSMFSLEL ITPPSNMLNK
730 740 750 760 770 780
MSILINNNNN NNNPQYQPEP ISSLDNIRRN LNILTYLEYS MNQYKTIPCQ QHNHSYPHNL
790 800 810 820 830 840
EIQTSIVHLP SVLTINVNLS NPEFKIINNF TQWLVPEFYA VKSKSISGKN GYSFKEIDHP
850 860 870 880 890 900
TPNSATQESG KYKYKYELLG YVCEINHQSD IVSGAHNLVA FIKVNNNGGW YLFNDFLVMP
910 920 930 940 950 960
IPEEEVFDLQ PSWKKPIVIM YQQTNQPSFN YLTTTTTTTT TTTTFSNAGK YDDSILYRDH
970 980 990 1000 1010 1020
FAEGIRKGHQ LEYELLTRKE SPQPGSLVAI DAEFVMLKPE ELEIHYDGYK KLIKPKQLSL
1030 1040 1050 1060 1070 1080
ARISVLRENG IPFIDDYIVH TSDIYDYLTN FSGIEPNDLN LTLSNRENLV TLQTAYRKLW
1090 1100 1110 1120 1130 1140
LLLNLGVIFV GHGLYNDFRT INLQVPERQI RDTAVIYYKS DFKRQLSLKF LAYVMLKEKV
1150 1160 1170 1180
QSGNHDSIED ANTALLLYKK YQNLYNKEDF ESILNYIYSE GQQLRFKVPE