Q5APF2

PR
Gene name
GUA1 (CAALFM_C109490CA, CaO19.12276, CaO19.4813)
Protein name
GMP synthase [glutamine-hydrolyzing]
Names
GMP synthetase, Glutamine amidotransferase
Species
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
KEGG Pathway
cal:CAALFM_C109490CA
EC number
6.3.5.2: Carbon--nitrogen ligases with glutamine as amido-N-donor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-40 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5APF2

Entry ID Method Resolution Chain Position Source
AF-Q5APF2-F1 Predicted AlphaFoldDB

No variants for Q5APF2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5APF2

No associated diseases with Q5APF2

5 regional properties for Q5APF2

Type Name Position InterPro Accession
domain GMP synthase, C-terminal 212 - 530 IPR001674
domain GMP synthase, glutamine amidotransferase 19 - 204 IPR004739
domain Glutamine amidotransferase 21 - 200 IPR017926
domain NAD/GMP synthase 229 - 294 IPR022310
domain GMP synthetase ATP pyrophosphatase domain 208 - 405 IPR025777

Functions

Description
EC Number 6.3.5.2 Carbon--nitrogen ligases with glutamine as amido-N-donor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GMP synthase activity Catalysis of the reaction: ATP + XMP + NH4(+) = AMP + diphosphate + GMP + 2H(+).
pyrophosphatase activity Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups.

3 GO annotations of biological process

Name Definition
glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid.
GMP biosynthetic process The chemical reactions and pathways resulting in the formation of GMP, guanosine monophosphate.
GMP metabolic process The chemical reactions and pathways involving GMP, guanosine monophosphate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSANIDDVPI EVSKVFDTIL VLDFGSQYSH LITRRLREFN VYAEMLPCTQ KIAELSWKPK
70 80 90 100 110 120
GIILSGGPYS VYAEDAPHVD HDIFKLGVPI LGICYGMQEL AWINGKGVAR GDKREYGPAT
130 140 150 160 170 180
LNVEDPECAL FKGVDHSQVW MSHGDKLHAL PTGFKVVATS DNSPFCGISN ESEHIYGIQF
190 200 210 220 230 240
HPEVTHTVQG KKLLKNFAVD ICQAKTNWSM ENFIDTEIAR IKKLVGPTAE VIGAVSGGVD
250 260 270 280 290 300
STVGAKIMKE AIGDRFHAIY VDNGVMRKNE TESVKKTLDE GLGINLTVVD AGDLFLGRLK
310 320 330 340 350 360
GVTDPEKKRK IIGNTFIHVF EEEAAKIKPR DGSEIEYLLQ GTLYPDVIES ISFKGPSQTI
370 380 390 400 410 420
KTHHNVGGLL EDMKLKLIEP LRELFKDEVR HLGELLGVPE DLVWRHPFPG PGLAIRVLGE
430 440 450 460 470 480
VTKEQVKIAR EADAIFIEEI KKAGLYRQIS QAFAALLPVK SVGVMGDQRT YEQVIALRAI
490 500 510 520
ETLDFMTADW FIFEAAFLKK VASRIVNEVD GVARVTYDIT SKPPATVEWE