Q5AK59

PR
Gene name
HAS1 (CAALFM_C504750CA, CaO19.11444, CaO19.3962)
Protein name
ATP-dependent RNA helicase HAS1
Names
Species
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
KEGG Pathway
cal:CAALFM_C504750CA
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-103 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5AK59

Entry ID Method Resolution Chain Position Source
AF-Q5AK59-F1 Predicted AlphaFoldDB

No variants for Q5AK59

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5AK59

No associated diseases with Q5AK59

7 regional properties for Q5AK59

Type Name Position InterPro Accession
conserved_site ATP-dependent RNA helicase DEAD-box, conserved site 259 - 267 IPR000629
domain Helicase, C-terminal 328 - 498 IPR001650
domain DEAD/DEAH box helicase domain 132 - 303 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 127 - 332 IPR014001
domain RNA helicase, DEAD-box type, Q motif 108 - 136 IPR014014
domain Domain of unknown function DUF4217 489 - 552 IPR025313
domain DDX18/Has1, DEAD-box helicase domain 119 - 316 IPR044773

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

2 GO annotations of biological process

Name Definition
maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.
ribosomal small subunit biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAKTTKVKGN KKKSDTSKVV SKVSRKRSHE DSESEVEDNE KVVEELDADF DEVAGLLGDD
70 80 90 100 110 120
IEDPESKSQS KKEKQKAKDE AKLEQLTKPQ VSNEVPDNDN DDDSSEDVLF ENADFSEPTM
130 140 150 160 170 180
KAIKEMGFTK MTKVQAKTIP PLLAGRDVLG AAKTGSGKTL AFLIPAIELL YSLKIKPRNG
190 200 210 220 230 240
TAVIIITPTR ELALQIFGVA RELMQFHSQT CGIVIGGADR RQEATKLAKG VNLLVATPGR
250 260 270 280 290 300
LLDHLKNTQF VFSNLKALVI DEADRILEIG FEDEMKQIIK VLPNENRQSM LFSATQTTKV
310 320 330 340 350 360
EDLARISLRP GPLYINVVPE KDVSTADGLE QGYVVCDSDK RFLLLFSFLK RNVKKKIIVF
370 380 390 400 410 420
LSSCNSVKFY SELLNYIDLP VLDLHGKQKQ QKRTNTFFEF CNAKQGILVC TDVAARGLDI
430 440 450 460 470 480
PAVDWIVQFD PPDDPRDYIH RVGRTARGTQ GKGKSLMFLT PSELGFLRYL KAAKVPLNEY
490 500 510 520 530 540
EFPANKIANI QSQLTKLIKT NYLLNQSAKD GYRAYLQAYA SHGLKTVYQI DKLDLKKVSA
550 560
SFGLDQVPRV NLSIGGTKTK KQKRS