Q5AK10

PR
Gene name
PAN3
Protein name
PAN2-PAN3 deadenylation complex subunit PAN3
Names
PAB1P-dependent poly(A)-specific ribonuclease, Poly(A)-nuclease deadenylation complex subunit 3, PAN deadenylation complex subunit 3
Species
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
KEGG Pathway
cal:CAALFM_C505170WA
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

22-220 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5AK10

Entry ID Method Resolution Chain Position Source
AF-Q5AK10-F1 Predicted AlphaFoldDB

No variants for Q5AK10

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5AK10

No associated diseases with Q5AK10

3 regional properties for Q5AK10

Type Name Position InterPro Accession
domain Zinc finger, CCCH-type 7 - 36 IPR000571
domain Protein kinase domain 332 - 660 IPR000719
domain Pan3 pseudokinase domain 569 - 693 IPR041332

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
P-body A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.
PAN complex A complex that possesses poly(A)-specific ribonuclease activity; catalyzes the message-specific shortening of mRNA poly(A) tails. Contains at least two subunits, known as Pan2p and Pan3p in Saccharomyces.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
poly(A) binding Binding to a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.

3 GO annotations of biological process

Name Definition
mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
nuclear-transcribed mRNA poly(A) tail shortening Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length.
protein phosphorylation The process of introducing a phosphate group on to a protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNINLDTAKD TLCKNILIYG YCKYENKGCA FSHNRQQPAQ QQQATNTSNN STSVITPNSA
70 80 90 100 110 120
NSTASSADLS SKKKFNLNTP SFQPSVSNLS NKFSTLSPKL KEIPVFKPEN GVSEPDTVDS
130 140 150 160 170 180
PTTQRPFTSK RFNVSTPSFT PTNFDFANNS NADGNRGGAS TPIGISSAPL VQNQQQQQQQ
190 200 210 220 230 240
QQQQQKQPLA VPSPLASGAQ PPTMQHRILS MGVSQSSPST NPYFANNLDM SAPTPGSETP
250 260 270 280 290 300
GPVLPGSAGA AAAAANQPMY PLQYHLYAPA PPPRLTIPLQ PYETNSQAMF IPNDLREYLH
310 320 330 340 350 360
KKNEASLQSL SHSNLPEHVN QYHSLVPIDK SYEPVSKLWL GKNSLIFKCL DNIDGNLYVM
370 380 390 400 410 420
RKIEPCNEII NEKPFKTIKR WKSIKNANIV GLQDAFTTMA FNGNQSGNTS LCIIYDYYPN
430 440 450 460 470 480
SISLLEHHKK GLRVEPVNEA LLWNYLIQLI NAIMAIHEKG LSASSTIDLS KIIVTNKNRI
490 500 510 520 530 540
KLSSVGISDI LEFKDDETNQ DIKIRQLQDI QKVGKVLMEL AILLLPVNMR QSNNIYNSLK
550 560 570 580 590 600
ASTNLSEEII NNLQELNDLD TASGEFDLNE FSQRLTPKMF NIIDSLQNSS DFIEGQLTSE
610 620 630 640 650 660
LENARLFRLM TKLNYLIHDN SNSENDKIIK LFLNYVYNCY DSNNKKVINL NKVLINLNKL
670 680 690
DCGIDEKILL VNNDECIIIS YKELKEIIDT KFRLMRE