Q5AIA4

PR
Gene name
IML1 (CAALFM_C102610WA, CaO19.10466, CaO19.2949)
Protein name
Vacuolar membrane-associated protein IML1
Names
Species
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
KEGG Pathway
cal:CAALFM_C102610WA
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

547-754 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5AIA4

Entry ID Method Resolution Chain Position Source
AF-Q5AIA4-F1 Predicted AlphaFoldDB

No variants for Q5AIA4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5AIA4

No associated diseases with Q5AIA4

2 regional properties for Q5AIA4

Type Name Position InterPro Accession
conserved_site Isocitrate/isopropylmalate dehydrogenase, conserved site 271 - 290 IPR019818
domain Isopropylmalate dehydrogenase-like domain 50 - 376 IPR024084

Functions

Description
EC Number
Subcellular Localization
  • Vacuole membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
extrinsic component of fungal-type vacuolar membrane The component of a fungal-type vacuolar membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
GATOR1 complex A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3. In S. cerevisiae, this complex is referred to as SEACIT and contains the Iml1p, Npr2p, and Npr3p proteins.

1 GO annotations of molecular function

Name Definition
GTPase activator activity Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.

4 GO annotations of biological process

Name Definition
filamentous growth of a population of unicellular organisms The process in which a group of unicellular organisms grow in a threadlike, filamentous shape.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
negative regulation of TORC1 signaling Any process that stops, prevents or reduces the frequency, rate or extent of TORC1 signaling.
positive regulation of autophagy Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQHPRMFNQT STNAKKPNGS DSSIKVANHS NQRQMSANHA SLTIGGSRNP INQRRSMSTK
70 80 90 100 110 120
NIGSTLIVSR RNNHYLDMKE EDSKENLTKI ISNNQNEEDT EVSVKVSVWF HELRDFTEDI
130 140 150 160 170 180
IIDENVIPTG VQAGQVFELQ SLDEGSSKKF VFTVQKRNLR SATNDTDYTE ASKPKLQISL
190 200 210 220 230 240
MANPFQRLLD LAPRSQVQLK RLVKLESVTV DSVEIFIKDV NLSRDAMWNF SASMIGNCVY
250 260 270 280 290 300
IDQRLLYLGS RVGVTKHIYK NGKNVTSGYV DKNTKIIYRS ESAKITLFVQ LSREMWHFEE
310 320 330 340 350 360
DGEIMFHKLI NNLFPKIFRR WRETNTHHSI TIVLFTSIDL TDIPWTNLGP GQRPPQRRDF
370 380 390 400 410 420
FRVVVDQVNS MHWDRIMEDL RLEFANFKRD TMLNLDDDGK FIIENGTLPA IKGNLLEAVN
430 440 450 460 470 480
LGLTSLNNRF QNTDLKHSIS HIMVITPGTG LFDVEHDLLL ETSKKMSSVD SSLDIICLSQ
490 500 510 520 530 540
PPLHVTPLFR YIKEGKVCHC VPLWCDISFF IDKVQQESQW IPRCKIYELQ MMGVMENEAS
550 560 570 580 590 600
DARIPRLHLN NYGKTLVEIM DEYDSAVFKP IKRIPKPAQV EFKQVKPKFQ APELKNATAT
610 620 630 640 650 660
LSLMFENKPL LQPSNSSTIS LATGTVANPS KDTSALSSLY YINKNSEEIK SPAPSVRSET
670 680 690 700 710 720
PVSTIRAIDS YRKSAGSPRL IRGETMFKRK EEIPNTEPPS ALSEKNAASA RKKSSILAEP
730 740 750 760 770 780
EQEISTGSFW IEISNPSQET TTNVLQRSQS SRWSNIFPNK IQRKLIKWRS FQAPASLPTT
790 800 810 820 830 840
TGVFPSTNQL QTDYTFQIYT VFLNSDNYWE LKSTHSLMRE MIQLRLMLGF QVCYGERVDK
850 860 870 880 890 900
AEAERKPSGN VDAIIKYFPE EHNYLGSRIY LAFGDEIHRI FCDYNGNINV QLYRKIIEND
910 920 930 940 950 960
EKKITLGQTK LKPYFPLIRT RYTDEYTPAR IDAIADNPQK FNWNQFDQLL AGFDDAMPEE
970 980 990 1000 1010 1020
KKQFHKMKFV VMPTDIPKNA YFVSNEKLTP EEIRVEGLRK LIGVIERGKY KHDSSQKKKS
1030 1040 1050 1060 1070 1080
RRGSDVIFYT GNLYDFLNEE AQNYDITGTQ PALMIPESSR FNKTIKLPDL AQELQDRNTG
1090 1100 1110 1120 1130 1140
LTLVDRTWHF KRHLHCFVGS ELVSWLVDCF EDIETREDAT TYGQNLMNKG LFKHVESRHG
1150 1160 1170 1180 1190 1200
LLDGHFFYEF SDEYVDKTDR EKPSWFGSKK IDGASTPQSN SSPRIAGQND LQKIISASNL
1210 1220 1230 1240 1250 1260
RSETSSTTDS MGRKRKKFIL SRSVKFDVDP LKKSFRPEFV TVHYDRVHNP EHCYHIRLQW
1270 1280 1290 1300 1310 1320
LNATTKFIED TITAWTRLCE RHGLKLVETP WNELCSLPKL SPFHSFVDIK LSVNPWTDPD
1330 1340 1350 1360 1370 1380
LCDDRILSSN RYYYHSYFLK QMGYYLDNRS TSFFSRENID IGYSWGKPTF RYAQFIHKTG
1390 1400 1410 1420 1430 1440
FYIVELRDNG DFFLAPNNMH LTRVRSSTTL VGDYENYSKG VLADSQTVML NFRAACQNKE
1450 1460
FLKETFTLAK SNWKDDYFSQ II