Q5AG40
Gene name |
VPS4 |
Protein name |
Vacuolar protein sorting-associated protein 4 |
Names |
|
Species |
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) |
KEGG Pathway |
cal:CAALFM_C503090WA |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5AG40
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5AG40-F1 | Predicted | AlphaFoldDB |
2 variants for Q5AG40
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| 4 | A>V | allele: CaO19.11814 [UniProt] | No | ||
| 102 | G>S | allele: CaO19.11814 [UniProt] | No |
No associated diseases with Q5AG40
6 regional properties for Q5AG40
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | AAA+ ATPase domain | 167 - 302 | IPR003593 |
| domain | ATPase, AAA-type, core | 171 - 299 | IPR003959 |
| conserved_site | ATPase, AAA-type, conserved site | 272 - 291 | IPR003960 |
| domain | MIT domain | 4 - 81 | IPR007330 |
| domain | Spastin/Vps4, C-terminal | 375 - 435 | IPR015415 |
| domain | Vacuolar protein sorting-associated protein 4, MIT domain | 6 - 80 | IPR045253 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| endosome membrane | The lipid bilayer surrounding an endosome. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to lithium ion | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus. |
| endosomal transport | The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane. |
| filamentous growth | The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape. |
| filamentous growth of a population of unicellular organisms | The process in which a group of unicellular organisms grow in a threadlike, filamentous shape. |
| hyphal growth | Growth of fungi as threadlike, tubular structures that may contain multiple nuclei and may or may not be divided internally by septa, or cross-walls. |
| late endosome to vacuole transport | The directed movement of substances from late endosomes to the vacuole. In yeast, after transport to the prevacuolar compartment, endocytic content is delivered to the late endosome and on to the vacuole. This pathway is analogous to endosome to lysosome transport. |
| protein secretion | The controlled release of proteins from a cell. |
| protein targeting to vacuole | The process of directing proteins towards the vacuole, usually using signals contained within the protein. |
| vacuole organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSGASDFLSK | GIDLVQKAID | ADTATRYEEA | YKLYYNGLDY | LMLAIKYEKN | PKSKELVKSK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FTEYLTRAEQ | LKDHLEKQAQ | NKSTAESSVN | GSTKAKKSNG | DGNGSGDDND | DADTKKLRGA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LAGAILSEKP | NVKWSDIAGL | DAAKEALKEA | VILPVKFPQL | FVGNRKPTSG | ILLYGPPGTG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KSYLAKAVAT | EANSTFFSVS | SSDLVSKWMG | ESERLVKQLF | TMARENKPSI | IFIDEVDALC |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GPRGEGESEA | SRRIKTELLV | QMNGVGNDSQ | GVLVLGATNI | PWQLDAAVRR | RFERRIYIAL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PDVEARTRMF | EINIGDVPCE | CTPHDYRTLA | EMTDGYSGHD | VAVVVRDALM | QPIRKIQQAT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| HFKPVIDETD | GKEKLTPCSP | GDEGAREMNW | MDLATDELKE | PPLTIKDFIK | AIKNNRPTVN |
| 430 | |||||
| EADIAQHVKF | TEDFGQEGN |