Q5ACU3

PR
Gene name
PMT5
Protein name
Dolichyl-phosphate-mannose--protein mannosyltransferase 5
Names
Protein mannosyltransferase 5
Species
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
KEGG Pathway
cal:CAALFM_CR09770CA
EC number
2.4.1.109: Hexosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-51 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5ACU3

Entry ID Method Resolution Chain Position Source
AF-Q5ACU3-F1 Predicted AlphaFoldDB

No variants for Q5ACU3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5ACU3

No associated diseases with Q5ACU3

3 regional properties for Q5ACU3

Type Name Position InterPro Accession
domain Glycosyl transferase family 39/83 39 - 277 IPR003342
domain MIR motif 303 - 495 IPR016093
domain Protein O-mannosyl-transferase, C-terminal four TM domain 514 - 716 IPR032421

Functions

Description
EC Number 2.4.1.109 Hexosyltransferases
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
dolichyl-phosphate-mannose-protein mannosyltransferase activity Catalysis of the reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein.

1 GO annotations of biological process

Name Definition
protein O-linked mannosylation The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTKELPSGYF QGPFRPYKTF QPSLTERPLS KFEQFAVFSI LLISLIRLYK LYIPDRVVFD
70 80 90 100 110 120
EIHLIKYIKN YYDGSIFVDI HPPLGKLIYF YITKLFSFDK DFQIDIIGDL YPEDFPYLWL
130 140 150 160 170 180
RLFSGICGIG HVLLTFFTLR ITCNSVISIV ITILICLENS MVTVSRLILL EGPSLFVQSL
190 200 210 220 230 240
VIYNYKAFTT RIPFTGCWYF NLFVTGIALG LNISLKISGL FTFAWVGILT CVQLWEILGD
250 260 270 280 290 300
LRISIWQFIK HLVLRVVAFI MVPLTIYCSV FYIHFENLPN EGPGSGFLTP HFRSTLDDYQ
310 320 330 340 350 360
QQPLQVLYGS TITIKHNALE KYLHSHDLTY PRGSNLQQVT LYDFPDVNNE WVIETKQKYN
370 380 390 400 410 420
EEKLMTDQRE VKDGDVVRLY HKATGHYLHV NDIRPPISEH EYSYEVNGNE TRGLLGNEDY
430 440 450 460 470 480
EFKIRMLVKK PHAENDLPLI KLRTTETIFQ LIHQATRCNL MSHEQKLPDW GEYQNEVLCV
490 500 510 520 530 540
KEPTIPNTLW YVESSSHPLL KDTKKLKTFP KFSFWSKLIE THKVMFNLNK GFTNPHPYAS
550 560 570 580 590 600
KPLDWPLLSR GIAFFSNYNL KSIDEESSLI YYLGNVAIYY SVFFVGLIAI FKCAIYSFIK
610 620 630 640 650 660
LNPYASPPSS SKSSPYANFY NNSWPYLVGW FINYIPYCLM SRNLYLHHYL SALNFGILLL
670 680 690 700 710 720
SQYLNYRVAK NKIIGGIITA TIFVSAIYCF YEFIPITYGL PWTLDQCNSH KWFPNWDIDC
MTYTG