Q5AAT0

PR
Gene name
RAI1
Protein name
Decapping nuclease RAI1
Names
CaRai1, NAD-capped RNA hydrolase RAI1, DeNADding enzyme RAI1
Species
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
KEGG Pathway
cal:CAALFM_C106800WA
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

111-187 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for Q5AAT0

Entry ID Method Resolution Chain Position Source
5BTH X-ray 220 A A 1-391 PDB
5BUD X-ray 199 A A/B 1-391 PDB
AF-Q5AAT0-F1 Predicted AlphaFoldDB

No variants for Q5AAT0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5AAT0

No associated diseases with Q5AAT0

1 regional properties for Q5AAT0

Type Name Position InterPro Accession
domain RAI1-like 224 - 291 IPR013961

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

6 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.
mRNA 5'-diphosphatase activity Catalysis of the removal of a 5' terminal diphosphate from the 5'-triphosphate end of an mRNA, leaving a 5'-monophosphate end.
nuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids.
nucleotide binding Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA NAD-cap (NAD-forming) hydrolase activity Catalysis of the reaction: a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + H(+) + NAD(+).

4 GO annotations of biological process

Name Definition
mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
NAD-cap decapping Cleavage of the 5'-NAD-cap of an RNA. The NAD-cap is present at the 5'-end of some RNAs in both bacetria and eukaryotes. While it promotes RNA stability in bacteria, it promotes RNA decay in eukaryotes.
nuclear-transcribed mRNA catabolic process The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells.
nucleic acid phosphodiester bond hydrolysis The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAKSLPLNSR SKTTALKQPR ELFSYARDID GKYVYDDPEN SLSYYYLPDS TIDTGIDLQG
70 80 90 100 110 120
GYSKFKKIPD EQNLADFNSL LKAIIKYETS EGKKISSDII TFREIMTKIL SLPYNLTDPI
130 140 150 160 170 180
DLYVVPFDGQ LFIKSDDELD MKRRKEQEVR MKQTNTVERY DYMKRCEYVG YKFETIATIP
190 200 210 220 230 240
KPWSQVSRSQ IENRNKKVVN NYEQYLSVIR TGIGNVKLVL AGEIDCCWDY LPDEQNKKLN
250 260 270 280 290 300
HYVELKTSRI IENNSQVVSF EQKLFKAWCQ CFLMGVTKII YGFRDNNLIL KNVELFNTEE
310 320 330 340 350 360
IPILIKNNPL TNAATEKKIN CTNALKWYGA VVDWLNTTVD KKDETKSYRL KYDPVRKSFT
370 380 390
LSETESETNE KLRNGELLTP EFTEWRQSLK K