Q5AAG6

PR
Gene name
MKC1
Protein name
Mitogen-activated protein kinase MKC1
Names
MAP kinase MKC1
Species
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
KEGG Pathway
cal:CAALFM_CR00120CA
EC number
2.7.11.24: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-96 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

191-218 (Activation loop from InterPro)

Target domain

28-339 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q5AAG6

Entry ID Method Resolution Chain Position Source
AF-Q5AAG6-F1 Predicted AlphaFoldDB

No variants for Q5AAG6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5AAG6

No associated diseases with Q5AAG6

3 regional properties for Q5AAG6

Type Name Position InterPro Accession
domain Protein kinase domain 28 - 339 IPR000719
conserved_site Mitogen-activated protein (MAP) kinase, conserved site 80 - 186 IPR003527
active_site Serine/threonine-protein kinase, active site 170 - 182 IPR008271

Functions

Description
EC Number 2.7.11.24 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
MAP kinase activity Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

19 GO annotations of biological process

Name Definition
cell wall integrity MAPK cascade A MAPK cascade that contributes to cell wall organization or biogenesis.
cellular response to heat Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
cellular response to oxidative stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
cellular response to reactive oxygen species Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
filamentous growth The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.
filamentous growth of a population of unicellular organisms in response to starvation The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to deprivation of nourishment.
fungal-type cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fungal-type cell wall.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
negative regulation of glucose mediated signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of glucose mediated signaling pathway.
negative regulation of mitotic cytokinesis Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cytokinesis.
positive regulation of calcium ion import across plasma membrane Any process that activates or increases the frequency, rate or extent of calcium ion import across plasma membrane.
positive regulation of calcium-mediated signaling Any process that activates or increases the frequency, rate or extent of calcium-mediated signaling.
positive regulation of filamentous growth of a population of unicellular organisms in response to starvation Any process that activates or increases the frequency, rate or extent of filamentous growth of a population of unicellular organisms in response to starvation.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of fungal-type cell wall organization Any process that modulates the rate, frequency or extent of the formation, arrangement of constituent parts, or disassembly of the fungal-type cell wall.
regulation of single-species biofilm formation on inanimate substrate Any process that modulates the frequency, rate or extent of single-species biofilm formation on inanimate substrate.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
single-species biofilm formation on inanimate substrate A process in which microorganisms of the same species attach to and grow on an inanimate surface such as a rock or pipe, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription.
stress-activated protein kinase signaling cascade The series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays a signal.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDQQEAPIYY GRSVNKVYNQ EFIIDSRFKI VKELGHGAYG IVCSAKYDNG SKKVPDSNNG
70 80 90 100 110 120
NASSSANASF VAIKKITNIF SKNILCKRAL RELKLLQFFR GHKNITCLYD LDIIPNPMTG
130 140 150 160 170 180
EFNEIYLYEE LMECDMHQII RSGQPLSDQH YQSFIYQVLC GLNFIHSADV LHRDLKPGNL
190 200 210 220 230 240
LVNADCELKI CDFGLARGFS ENPDENAGFM TEYVATRWYR APEIMLSFTN YTKAIDIWSV
250 260 270 280 290 300
GCILAELLGG KPLFRGKDYV DQLNQILMIL GTPPESTLQR IGSHRAQNYV RSLPITRKAS
310 320 330 340 350 360
YEELFPDANP LALDLLERML TLDPRERITV RDALNHKYLE LWHDPKEEIE CQVKFDFKSF
370 380 390 400 410 420
ETVDGLDEMK QLIMDEVQKF REFVRKPIEE QQRIQMQLHM QKREEQRQEE EEKELLEQQR
430 440 450 460 470 480
QFPAQESMDI SQTPYNNLET NIGTPQVEDD YPRPQELDEF TFSNLESSSS MNLFQDMAKP
490 500
SGEEYIKLEE ELGFGLDGAM FNNYCNDHQ