Q5A762

PR
Gene name
MLT1 (ABC1, BPT1, YCF1)
Protein name
Multiple drug resistance-associated protein-like transporter 1
Names
MRP-like transporter 1, Vacuolar multi-drug resistance ABC transporter MTL1
Species
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
KEGG Pathway
cal:CAALFM_C108210CA
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

889-995 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5A762

Entry ID Method Resolution Chain Position Source
AF-Q5A762-F1 Predicted AlphaFoldDB

No variants for Q5A762

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5A762

No associated diseases with Q5A762

10 regional properties for Q5A762

Type Name Position InterPro Accession
domain ABC transporter-like, ATP-binding domain 672 - 905 IPR003439-1
domain ABC transporter-like, ATP-binding domain 1345 - 1600 IPR003439-2
domain AAA+ ATPase domain 696 - 898 IPR003593-1
domain AAA+ ATPase domain 1371 - 1577 IPR003593-2
domain ABC transporter type 1, transmembrane domain 326 - 613 IPR011527-1
domain ABC transporter type 1, transmembrane domain 1027 - 1308 IPR011527-2
conserved_site ABC transporter-like, conserved site 805 - 819 IPR017871-1
conserved_site ABC transporter-like, conserved site 1502 - 1516 IPR017871-2
domain ABC transporter C family, six-transmembrane helical domain 2 1023 - 1320 IPR044726
domain ABC transporter C family, six-transmembrane helical domain 1 327 - 621 IPR044746

Functions

Description
EC Number
Subcellular Localization
  • Vacuole membrane; Multi-pass membrane protein
  • Associates with lipid rafts in a RTA2-dependent manner
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
fungal-type vacuole A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure.
fungal-type vacuole membrane The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

5 GO annotations of molecular function

Name Definition
ABC-type peptide transporter activity Catalysis of the reaction: ATP + H2O + peptide(in) = ADP + phosphate + peptide(out). Peptides exported include alpha-hemolysin, cyclolysin, colicin V and siderophores from Gram-negative bacteria, and bacteriocin, subtilin, competence factor and pediocin from Gram-positive bacteria.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATPase-coupled transmembrane transporter activity Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source.
bilirubin transmembrane transporter activity Enables the transfer of bilirubin from one side of a membrane to the other. Bilirubin is a linear tetrapyrrole produced in the reticuloendothelial system from biliverdin and transported to the liver as a complex with serum albumin. In the liver, bilirubin is converted to bilirubin bisglucuronide, which is excreted in the bile.
cadmium ion transmembrane transporter activity Enables the transfer of cadmium (Cd) ions from one side of a membrane to the other.

7 GO annotations of biological process

Name Definition
cellular response to starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
filamentous growth The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.
filamentous growth of a population of unicellular organisms in response to biotic stimulus The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a biotic (living) stimulus.
filamentous growth of a population of unicellular organisms in response to starvation The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to deprivation of nourishment.
transmembrane transport The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
vacuole fusion, non-autophagic The fusion of two vacuole membranes to form a single vacuole.
xenobiotic detoxification by transmembrane export across the plasma membrane A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNESNRELIL GLSPVHLSLF NSESLLHTFN FFGVGDGQAN IASNYVTASK FVIPQPLYSP
70 80 90 100 110 120
HGNALNPAFV ELIGQAVNTF FAIFMLFQLT RLLLTKKKSH RIYTPTPFSQ TLKISLVLLQ
130 140 150 160 170 180
VILVASLYFL NKNSYFIGGI AATVLALILH LVEFRRSPIA IESLLTYWSA NTAFTFAVFI
190 200 210 220 230 240
QDSYSKHKIY ANSGPAYVIE IISLVNSFLI FVFEVGYYKP GFEITNEKFL DTVNLFSYFT
250 260 270 280 290 300
FYYLQPLINK IYATDDVQLT DLPDILGNIT CDDTKAKVAK AWEEELKRTK KPGLVSKVWS
310 320 330 340 350 360
FVTRRKVNSK PQMFLAIAKA FFDKFAISIT LAIIVTGLSF LQPFLLRKFI QFFSTYFYSV
370 380 390 400 410 420
EKPPIIIGYF WASVMFLTSV ANFIAFNQAF KTQFDLGYEI QSSLTTLIYE KALRLSPQSR
430 440 450 460 470 480
KNKPTGDIIN HITMDIDIIF WFCWQLGEYL ASPLKLAVCL AALYKLFSNA TWAGVITAII
490 500 510 520 530 540
VAPLATLVNA SMSKNYIQLM KDKDERTSLI TEILNSAKSI KFYSWEKPML ARLSHIRNDR
550 560 570 580 590 600
ELNNIKKIGV VSALAQFLWS CIPFFISCAT YATYAYFYNV PLTPDIVFPA LALFDLLSEP
610 620 630 640 650 660
MLLIPSFIVE VIEVSTSLAR IGELLCLDEL ADDQHGYVKR DPEPNDNSIY SVIVKDATFV
670 680 690 700 710 720
WSEETQQKQY TDEESEVQEV PASNVALKNI NFSARKGELA CIVGKVGSGK STLIKAILGD
730 740 750 760 770 780
VPIKIPSYSD DSTNPTPSVE TFGSIAYCPQ NPWILNGTVK ENILFGHKYD AEFYQKTIDA
790 800 810 820 830 840
CELISDFKNL PDGDQTVVGE KGISLSGGQK ARISLARSVY TRADIYLLDD ILSAVDAHVG
850 860 870 880 890 900
KNIIKKVLSN EGLIGNRCRI LATNSVPVLH EANDIYLIAG GAFVEHGKFK EVMKRNGDLA
910 920 930 940 950 960
KLIKEYGRKK DEPTEEETTE ASTEPKEEDH SNGKSDTAVH DELDTDELVD EIVDYVGEQN
970 980 990 1000 1010 1020
RGVVEQAILR RASVVSYGHN YENDEADNGQ IRKTRHEQEE SRKGTVPWDI FKQYIIACDY
1030 1040 1050 1060 1070 1080
KYFSFYVAAT FSVVLISAGE KYLLSYWSQL NSEQNDTVEP VFFLGTYATL GVVSGFLTYM
1090 1100 1110 1120 1130 1140
GALVIWSYCI VKGSTYFHNK MAESVLRSPM SFFDTTPIGR ILNRFTEDIG KIDMNLPWTI
1150 1160 1170 1180 1190 1200
ISFITTLLNG FVTFGVILSF LPLMLVVIVS LLFVYNYFRI RFVPTTRELK RLESIAKSPV
1210 1220 1230 1240 1250 1260
LATIQESING VETIKAFHQR ERFVYKSKKL IDEKTLIGVV QQNCNRWLSM RLQTISSSIM
1270 1280 1290 1300 1310 1320
FFTALLAVVT LGGKHPILPS ILGFVMTYSM SITYILNSLV RIWAEMQAGG VAIERIIEYC
1330 1340 1350 1360 1370 1380
DLPSEAPMII EDKRPQDSWP AHGVVKFKKY STAYRKHLDP VLREIELTIN SKEKVGIVGR
1390 1400 1410 1420 1430 1440
TGAGKSSLTL ALFRIIEATG GNIEIDGVDT SQIGLYDLRH HLTIIPQEAH TFRASVRENL
1450 1460 1470 1480 1490 1500
DPFGEYSDDK LWKVLELAHL KEHVTKMETD PTEEEKKASK NPDELSKKVG LDAQIEEGGS
1510 1520 1530 1540 1550 1560
NLSSGQKQLL CLARALLNET SKILVLDEAT AAVDFQTDKI IQETIRTEFK DKTILTIAHR
1570 1580 1590 1600
IDTIMDSDKI LVLDSGKVAE FDSPQNLLKN KDSIFYSLAK EGGYID