Q5A761
PR
Gene name |
CCR4 (CAALFM_C108220WA, Ca41C10.13c, CaO19.12567, CaO19.5101) |
Protein name |
CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4 |
Names |
Carbon catabolite repressor protein 4, Cytoplasmic deadenylase, Glucose-repressible alcohol dehydrogenase transcriptional effector |
Species |
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) |
KEGG Pathway |
cal:CAALFM_C108220WA |
EC number |
3.1.13.4: Exoribonucleases producing 5'-phosphomonoesters |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5A761
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5A761-F1 | Predicted | AlphaFoldDB |
No variants for Q5A761
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5A761 | |||||
No associated diseases with Q5A761
5 regional properties for Q5A761
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | Leucine-rich repeat | 296 - 359 | IPR001611 |
| repeat | Leucine-rich repeat, typical subtype | 316 - 335 | IPR003591-1 |
| repeat | Leucine-rich repeat, typical subtype | 336 - 359 | IPR003591-2 |
| repeat | Leucine-rich repeat, typical subtype | 361 - 381 | IPR003591-3 |
| domain | Endonuclease/exonuclease/phosphatase | 459 - 769 | IPR005135 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.13.4 | Exoribonucleases producing 5'-phosphomonoesters |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| CCR4-NOT complex | The Ccr4-Not complex is an eukaryotically conserved deadenylase that can initiate cytoplasmic mRNA decay, and reduce translation by releasing poly(A)-binding protein (Pab1/PABPC1). Ccr4-Not contains seven core subunits, including two poly(A)-specific exonucleases, Ccr4/CNOT6/CNOT6L and Caf1/Pop2/CNOT7/CNOT8. |
| CCR4-NOT core complex | The core of the CCR4-NOT complex. In Saccharomyces the CCR4-NOT core complex comprises Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p. |
| Cdc73/Paf1 complex | A multiprotein complex that associates with RNA polymerase II and general RNA polymerase II transcription factor complexes and may be involved in both transcriptional initiation and elongation. In Saccharomyces the complex contains Paf1p, Cdc73p, Ctr9p, Rtf1p, and Leo1p. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| P-body | A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| 3'-5'-exoribonuclease activity | Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. |
| metal ion binding | Binding to a metal ion. |
| poly(A)-specific ribonuclease activity | Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA replication checkpoint signaling | A signal transduction process that contributes to a DNA replication checkpoint, that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome. |
| nuclear-transcribed mRNA poly(A) tail shortening | Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length. |
| positive regulation of transcription elongation by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II. |
| replication fork protection | Any process that prevents the collapse of stalled replication forks. |
| transcription elongation by RNA polymerase II promoter | The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II. |
| traversing start control point of mitotic cell cycle | A cell cycle process by which a cell commits to entering S phase via a positive feedback mechanism between the regulation of transcription and G1 CDK activity. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNITNKFQHT | PIQGQPQSNL | QAQQILLSQL | HQGQAQQQQQ | QQQQQQQQQQ | SSAGVLGSGF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QPSDNFGESL | NQNIYQNNYQ | RAQPSLQQQF | FPQFQQSQQQ | PSQQANNASQ | LQQPYQPAQQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MVRQTSHFQQ | QQQQQPSSQQ | FYSQQQASVL | QQQQQQQIQL | QSAHQQQSSL | LNMNSINVDN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PNSVYWQHQQ | QLCQISRGSN | VPHYYARQYA | SNSRKAKNPY | SEVKSVGLVE | ATRSMVASLE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DEEEKKKKPI | NYQGTPTTSA | ALLHNKKSTQ | DIFEDDSMEE | QRMRLKTQGK | QLWCQLDLSG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QGLVNISSKL | FHYDFLESLY | LSNNKLNSIP | SSISKLRNLR | TLDLSHNRIN | ELPEELGLCF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NLRYLFLFDN | NIKTLPYSFG | NMIELLFIGI | EGNPLEPSIA | NLIAEKGTKE | LIATLRDQTT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VKRTPKPRCW | LTLEDDGEVV | DSDEVYKVEP | ESSDNFTVLS | YNTLCQHYAT | PKMYKFTPSW |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ALQWDYRKNL | LEKEVLNYNT | DIVCMQEVET | KTFQEFWLPV | MTANGYKGYF | FSKTRSKTMS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ETDSKKVDGC | ATFFKNDKFS | LIHKQNFEYN | SVCMGSDKYK | KTKDLFNRFM | NKDNIALISY |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LQHKESGEKI | AVVNTHLHWD | PAFNDVKALQ | VGILLEELQG | IIKKYRHTNS | NEDIKNSSIV |
| 670 | 680 | 690 | 700 | 710 | 720 |
| VCGDFNSVKD | SAVYQLFSTG | ASKGHEDMNG | RDYGKFTEDG | FHHPFKLKSA | YEAVGELPFT |
| 730 | 740 | 750 | 760 | 770 | 780 |
| NLTPAFTDNI | DYIWYSTPTL | QVKGLLGGVD | EEYTSHSIGF | PDANFPSDHV | PILAKFQLKK |
| GKKNHSV |