Q5A6A4

PR
Gene name
KAE1
Protein name
tRNA N6-adenosine threonylcarbamoyltransferase
Names
N6-L-threonylcarbamoyladenine synthase, t(6)A synthase, t(6)A37 threonylcarbamoyladenosine biosynthesis protein KAE1, tRNA threonylcarbamoyladenosine biosynthesis protein KAE1
Species
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
KEGG Pathway
cal:CAALFM_C404920WA
EC number
2.3.1.234: Transferring groups other than amino-acyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

215-290 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5A6A4

Entry ID Method Resolution Chain Position Source
AF-Q5A6A4-F1 Predicted AlphaFoldDB

No variants for Q5A6A4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5A6A4

No associated diseases with Q5A6A4

2 regional properties for Q5A6A4

Type Name Position InterPro Accession
domain Gcp-like domain 13 - 370 IPR000905
conserved_site Peptidase M22, conserved site 118 - 138 IPR017860

Functions

Description
EC Number 2.3.1.234 Transferring groups other than amino-acyl groups
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
chromatin The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
EKC/KEOPS complex A protein complex involved in t6A tRNA modification. For example, in Saccharomyces cerevisiae the complex contains Bud32p, Kae1p, Gon7p, Cgi121p, and Pcc1p.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
chromatin DNA binding Binding to DNA that is assembled into chromatin.
metal ion binding Binding to a metal ion.
N(6)-L-threonylcarbamoyladenine synthase activity Catalysis of the reaction: L-threonylcarbamoyladenylate + adenine(37) in tRNA = AMP + N(6)-L-threonylcarbamoyladenine(37) in tRNA.

3 GO annotations of biological process

Name Definition
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
telomere maintenance via recombination Any recombinational process that contributes to the maintenance of proper telomeric length.
tRNA threonylcarbamoyladenosine modification The attachment of a carbonyl group and a threonine to the amino group of the adenine residue immediately 3' of the anticodon, in tRNAs that decode ANN codons (where N is any base).

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVVDLDKYLK PGKDHYLALG LEGSANKLGV GVIKHNKGPL SSTNRAEVLS NIRDTYITPP
70 80 90 100 110 120
GEGFLPRDTA RHHRNWVVRI IKQALATAKI AGKDIDVICF TQGPGMGAPL QSVVIAARTL
130 140 150 160 170 180
AQLWNIPIVG VNHCVGHIEM GREITGAENP VVLYVSGGNT QVIAYSKQRY RIFGETLDIA
190 200 210 220 230 240
IGNCLDRFAR TLKIPNEPAP GYNIEQMAKK GKHLVPLPYT VKGMDLSMSG ILAAIDSIAK
250 260 270 280 290 300
EMFGKQQKKL IDEESGEPIT AEDLCFSLQE TLFSMLVEIT ERALAHVDSN QVLIVGGVGS
310 320 330 340 350 360
NQRLQEMMKL MIQDRKNGQI YATDERFCID NGIMIAHAGL LSYRTGQTNQ LNNTVCTQRF
370
RTDEVFVKWR DD