Q5A688

PR
Gene name
PMT6 (PMT3, CAALFM_C404780WA, CaO19.11283, CaO19.3802)
Protein name
Dolichyl-phosphate-mannose--protein mannosyltransferase 6
Names
Protein mannosyltransferase 6
Species
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
KEGG Pathway
cal:CAALFM_C404780WA
EC number
2.4.1.109: Hexosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-106 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5A688

Entry ID Method Resolution Chain Position Source
AF-Q5A688-F1 Predicted AlphaFoldDB

No variants for Q5A688

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5A688

No associated diseases with Q5A688

3 regional properties for Q5A688

Type Name Position InterPro Accession
domain Glycosyl transferase family 39/83 97 - 357 IPR003342
domain MIR motif 383 - 595 IPR016093
domain Protein O-mannosyl-transferase, C-terminal four TM domain 614 - 830 IPR032421

Functions

Description
EC Number 2.4.1.109 Hexosyltransferases
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name Definition
dolichyl-phosphate-mannose-protein mannosyltransferase activity Catalysis of the reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein.

8 GO annotations of biological process

Name Definition
cellular response to neutral pH Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a neutral pH (pH close to 7) stimulus. pH is a measure of the acidity or basicity of an aqueous solution.
cellular response to starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
filamentous growth The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.
filamentous growth of a population of unicellular organisms The process in which a group of unicellular organisms grow in a threadlike, filamentous shape.
filamentous growth of a population of unicellular organisms in response to neutral pH The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a neutral pH (pH close to 7) stimulus.
filamentous growth of a population of unicellular organisms in response to starvation The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to deprivation of nourishment.
protein O-linked mannosylation The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage.
single-species biofilm formation on inanimate substrate A process in which microorganisms of the same species attach to and grow on an inanimate surface such as a rock or pipe, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MATGYSTGVS PFDLDENNHN DSIHHRHQNH HSQSHDSSGE RDDTEIEDII QKTSKLNINT
70 80 90 100 110 120
STSTKIKNFF FQSSNRHDSS NSPPLREVFI KTINPLILTA ISSFVRLYRI DVANSVVWDE
130 140 150 160 170 180
AHFGKFGSQY LKRQFYFDVH PPLGKLLIGL SGYLADYDGN FDFESSNVYP DNVNYVFMRI
190 200 210 220 230 240
FNCFFGILVT PLAYKTAVIL GYNQFTCWLI AFMVIFEQLS LTLSKFILLD SMLLFFTVLT
250 260 270 280 290 300
MYCLVKVHTL AIARVGSNSK TPLTKLEIKW YILTGISIGC VCSVKWVGLF VTALVGFYTI
310 320 330 340 350 360
VDLWIKFYQT FAIDKKSPKK MSVVNYLIHW VVRIFTLIII PMTIYVATFK VHFMVLNHTG
370 380 390 400 410 420
PDDGTLSTLL QGSLIGNDLQ SGPRSVAFGS LVTIRSQGLS PNLIHSHPHN YPQGSQEQQV
430 440 450 460 470 480
TTYGFKDDNN EFLFEFGVDA GLRNQHATLE NENSTRNGGN DDDYYHVIIH DGDTVRINHK
490 500 510 520 530 540
NTGSYLRANA VGAPITSSSY EVSCFGDVES NDWADEWVIE IQSQDQSPDP MFQDEDPSEI
550 560 570 580 590 600
HSVSTSFRLK HKQLGCYLAT TGKSYPAWGY QQGEVVCKYS VFSRDKNTWW NIEKHVNNKL
610 620 630 640 650 660
PLPATEYVPP KPKFWKEFIL LNYAMMASNN ALIPDPDRFD KLSSEWWEWP ILNTGLRMNS
670 680 690 700 710 720
WGDADIKYFL LGNPLITWIS TIALIVCPLY LLVVGIKYQR QWILLSATDT SNANPANSQS
730 740 750 760 770 780
LSLLAARALL PLAGWVLHYV PFILMGRVKY LHHYVPALYF AIFVAGFIVD AILNLDFSYH
790 800 810 820 830
NNKFQYIFKV VIYSTLYLVI CISFWYFKDL SFGMEGSSVD YRHLRLLGSW MI