Q5A3Y5
Gene name |
THI13 (THI5) |
Protein name |
4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase |
Names |
HMP-P synthase, Hydroxymethylpyrimidine phosphate synthase, Thiamine biosynthesis protein 5, Thiamine pyrimidine synthase |
Species |
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) |
KEGG Pathway |
cal:CAALFM_CR09290WA |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5A3Y5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5A3Y5-F1 | Predicted | AlphaFoldDB |
No variants for Q5A3Y5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5A3Y5 | |||||
No associated diseases with Q5A3Y5
1 regional properties for Q5A3Y5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | SsuA/THI5-like | 16 - 238 | IPR015168 |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase activity from histidine and PLP | Catalysis of the reaction: 2 Fe(3+) + 4 H2O + L-histidyl- + N(6)-(pyridoxal phosphate)-L-lysyl- = (2S)-2-amino-5-hydroxy-4-oxopentanoyl- + 3-oxopropanoate + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 2 Fe(2+) + 2 H(+) + L-lysyl- |
| metal ion binding | Binding to a metal ion. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| thiamine biosynthetic process | The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. |
| thiamine diphosphate biosynthetic process | The chemical reactions and pathways resulting in the formation of thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSTNKITFLL | NWEAAPYHIP | VYLANIKGYF | KDENLDIAIL | EPSNPSDVTE | LVGSGKVDMG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LKAMVHTLAA | KARGLPVTSI | GSLLDEPFTG | ICYLEGSGIT | SDFQSLKGKR | IGYVGEFGKI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QVDELTKHYG | MTPDDYVAVR | CGMNVAKYIL | EGTIDCGIGI | ECIQQVELEE | ALKEQGKDSN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DAKMLRIDKL | AELGCCCFCT | ILYIANDKFI | AENSQAVKKF | LKAIKRATDY | MLAHPREAWA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EYGNFKPTMQ | TDLNTKKFQR | CYAYFSESLY | NVHRDWRKVN | NYGKRLDILP | ENYVPNYTNE |
| 310 | 320 | 330 | |||
| YLSWPEPKEV | DDPEKAQDLM | LKHQEECKTC | GGYKRLVLA |