Q5A3P6

PR
Gene name
PKH2
Protein name
Serine/threonine-protein kinase PKH2
Names
PKB-activating kinase homolog 2
Species
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
KEGG Pathway
cal:CAALFM_C112410CA
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

70-250 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

381-389 (Activation loop from InterPro)

Target domain

240-502 (Protein kinase domain)

Relief mechanism

Assay

405-413 (Activation loop from InterPro)

Target domain

240-502 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

2 structures for Q5A3P6

Entry ID Method Resolution Chain Position Source
4C0T X-ray 316 A A 1-944 PDB
AF-Q5A3P6-F1 Predicted AlphaFoldDB

No variants for Q5A3P6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5A3P6

No associated diseases with Q5A3P6

3 regional properties for Q5A3P6

Type Name Position InterPro Accession
domain Protein kinase domain 240 - 502 IPR000719
active_site Serine/threonine-protein kinase, active site 360 - 372 IPR008271
binding_site Protein kinase, ATP binding site 246 - 269 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Nucleus
  • Cytoplasm, cell cortex
  • Localizes at eisosomes, large, immobile complexes that mark sites of endocytosis near the plasma membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cell cortex The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
lipid binding Binding to a lipid.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

3 GO annotations of biological process

Name Definition
endocytosis A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
peptidyl-serine phosphorylation The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MHKFRYSLHQ HYSKRNSSDK SKDSPISQNS NEENDSTKLS SSSLQDLHDD LDDIYNNYTL
70 80 90 100 110 120
AQGTNNNSVD TLDSENNQAI NKFIDKPPAI HGMEPQLPVM HVSSRLSSLG NTTNETGESI
130 140 150 160 170 180
AKSAPGTPLS SHSFDFRPHH PRAVTNSSLN VLLDTPNVSS EFNHLVDQTP PNESVERFDD
190 200 210 220 230 240
SNNTVDNTEE EENNDDTDEI PKSETLKQNE ENWEKKGAAV KTIKTMDGEM KTIRRNVTDF
250 260 270 280 290 300
KFGKELGEGS YSTVILATDK ITGKQYAVKV LDKRHIIKEK KVKYVNIEKH ALNRLSNRLG
310 320 330 340 350 360
VISLYFTFQD KDSLYFVLDY ASNGELLTLI KRYNTLNEEC TRHFGAQILD AIKYMHDNGV
370 380 390 400 410 420
IHRDLKPENI LLDDKMRIQI TDFGTARLLE KKNDESEEYP VDVRAKSFVG TAEYVSPELL
430 440 450 460 470 480
ENKYCGKPGD VWAFGCIIYQ MIAGKPPFKA TNEYLTFQKI TKLQFAFSAG FPTIIRDLIK
490 500 510 520 530 540
KILVLQPSRR ATIPEIQKHY FFQSVDFKDF DSIWLSDPPE IGPYKMTAKS MMKVPELNKA
550 560 570 580 590 600
PITTVIKKNV KKSTNSNSNT NNVATAVGGS SSNGHKGSSP TPEKEPSPAT INNKSTEKVS
610 620 630 640 650 660
AASVAAYVLN KPATNQNSST SEDSSKRSSN SNETRKLSYS QQDYIPGTNI LRPQISTRPS
670 680 690 700 710 720
VGSYVKTTPS KDRKTLTKVP SNIHQQQEKV KPKVMEVKPA TTLEAAWEPY LTHPDERILR
730 740 750 760 770 780
IGPVIAHKEP TEPFEKKNKA SLHISPLDIN KEQRSRSNTS LLTQIVNEVN NNTSELKKVE
790 800 810 820 830 840
NADESLAIIE PQYNMKRSPT SDSKKSMDIE RSASTSGSRI SKKAIFKKLG FSHLEKNDSE
850 860 870 880 890 900
ESNGPSLTEK PQTCTLVVTT HGRALLFIRN DIESNYLLIA EIKLKYPFIH FQELVISQTK
910 920 930 940
FSKLVPSVGV FVISSIDNSL IFEVEKFEVN QWTEALAKSK YNEIGKR