Q5A0Y8

PR
Gene name
MGT1 (CAALFM_C407010CA, CaO19.10620, CaO19.3108)
Protein name
Methylated-DNA--protein-cysteine methyltransferase
Names
6-O-methylguanine-DNA methyltransferase, MGMT, DNA repair MTase, O-6-methylguanine-DNA-alkyltransferase
Species
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
KEGG Pathway
cal:CAALFM_C407010CA
EC number
2.1.1.63: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

21-92 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5A0Y8

Entry ID Method Resolution Chain Position Source
AF-Q5A0Y8-F1 Predicted AlphaFoldDB

No variants for Q5A0Y8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5A0Y8

No associated diseases with Q5A0Y8

1 regional properties for Q5A0Y8

Type Name Position InterPro Accession
domain BTB/POZ domain 9 - 87 IPR000210

Functions

Description
EC Number 2.1.1.63 Methyltransferases
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
methylated-DNA-[protein]-cysteine S-methyltransferase activity Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine.

3 GO annotations of biological process

Name Definition
DNA dealkylation involved in DNA repair The repair of alkylation damage, e.g. the removal of the alkyl group at the O6-position of guanine by O6-alkylguanine-DNA alkyltransferase (AGT).
filamentous growth of a population of unicellular organisms The process in which a group of unicellular organisms grow in a threadlike, filamentous shape.
methylation The process in which a methyl group is covalently attached to a molecule.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSNLYYTVFD TDVCTVLLVL TLNGFVCYAS LGKPAIELKG IMAKDFSSLP YQLKPLSTMT
70 80 90 100 110 120
GDKIEIDKSV EKFKLLVETP SVSQDIKTEL LFGTPLQRKV WKELVKIPAG QTRTYKELAD
130 140 150 160 170
LLGTHSRVIG NCCGANRIAV LIPCHRVVGA NNKLTGYRWG KSYKEYLLKQ EGIGI