Q59X23

PR
Gene name
PMT4
Protein name
Dolichyl-phosphate-mannose--protein mannosyltransferase 4
Names
Protein mannosyltransferase 4
Species
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
KEGG Pathway
cal:CAALFM_C206100WA
EC number
2.4.1.109: Hexosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-66 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q59X23

Entry ID Method Resolution Chain Position Source
AF-Q59X23-F1 Predicted AlphaFoldDB

No variants for Q59X23

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q59X23

No associated diseases with Q59X23

3 regional properties for Q59X23

Type Name Position InterPro Accession
domain Glycosyl transferase family 39/83 53 - 298 IPR003342
domain MIR motif 325 - 523 IPR016093
domain Protein O-mannosyl-transferase, C-terminal four TM domain 545 - 748 IPR032421

Functions

Description
EC Number 2.4.1.109 Hexosyltransferases
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p homodimer complex A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt4p.
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
dolichyl-phosphate-mannose-protein mannosyltransferase activity Catalysis of the reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein.
identical protein binding Binding to an identical protein or proteins.
mannosyltransferase activity Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid.

10 GO annotations of biological process

Name Definition
cell wall mannoprotein biosynthetic process The chemical reactions and pathways resulting in the formation of cell wall mannoproteins, any cell wall protein that contains covalently bound mannose residues.
cellular response to neutral pH Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a neutral pH (pH close to 7) stimulus. pH is a measure of the acidity or basicity of an aqueous solution.
filamentous growth The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.
filamentous growth of a population of unicellular organisms The process in which a group of unicellular organisms grow in a threadlike, filamentous shape.
filamentous growth of a population of unicellular organisms in response to neutral pH The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a neutral pH (pH close to 7) stimulus.
fungal-type cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fungal-type cell wall.
negative regulation of proteolysis Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.
protein O-linked mannosylation The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage.
regulation of endoplasmic reticulum unfolded protein response Any process that modulates the frequency, rate or extent of endoplasmic reticulum unfolded protein response.
single-species biofilm formation on inanimate substrate A process in which microorganisms of the same species attach to and grow on an inanimate surface such as a rock or pipe, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSQTLKKRGG NSSGRKSPTT SNIEFDDKKT EFDLNAIVPP KEPEYKYLAA LTLVTLLAIY
70 80 90 100 110 120
TRFTKLGTPN KVVFDEVHFG KFASYYLERT YFFDLHPPFA KLLIAFVGWL IGYDGKFKFE
130 140 150 160 170 180
AIGDSYIENN VPYIAYRSLS AIQGAAIVPI MFLTMKTLGF SVAACLFSSI IVCFDNAQVT
190 200 210 220 230 240
DSRLILLDAT LILSVALTIF SYSKFSTFRK QSFSSKWWTW LLATGVSLSC VISTKYVGVF
250 260 270 280 290 300
TYLTIGIAVI HELWILLDYR KGLTLQEFAK HFFARLWALI IVPFCIYLYW FYLHFAILTR
310 320 330 340 350 360
SGPGDAFMSS EFQETLLESP LAAHSKPVQY FDQITIKHKD TGAFLHSHQH EYPLRYEDGR
370 380 390 400 410 420
ISSNGQQVTC VVQENAANDP NNQWEIVPTS EGANKGTKVY TNDIVRFRHV GTGGYLLTHD
430 440 450 460 470 480
VASPLKPTNE EFTVVYDDVA QQRYNETLFR LRLHVPGSNP KKEKNKKEIK TLATDLRILH
490 500 510 520 530 540
VDTVVAMWTH NDELLPEWAF NQQEVSGNKK IPDKDNIWNF DLITNLQSTD PRNQYVPKKV
550 560 570 580 590 600
KTLPFLRKWW ELQMLMFHHN NQLSSEHPFA TQPGEWPLAL SGVSFYNDNT EKKQIFFIGN
610 620 630 640 650 660
IIGFWLEVCF LSIYIGILLA DQITRRRNVH VLSDRARSRL YNTLGFLFVG WAAHYLPFFL
670 680 690 700 710 720
MNRQKFLHHY LPAHLVAALF SGGLVEFICS NNSARPNGKP VGVNKYKIIA VVAACSTAII
730 740 750
WFFFYFRPLT YGDVYLTPEE VKARQWLDIK LHYGK