Q59UY7

PR
Gene name
SEF1 (CAALFM_CR02190CA, CaO19.11237, CaO19.3753)
Protein name
Transcriptional regulatory protein SEF1
Names
Species
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
KEGG Pathway
cal:CAALFM_CR02190CA
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-105 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q59UY7

Entry ID Method Resolution Chain Position Source
AF-Q59UY7-F1 Predicted AlphaFoldDB

No variants for Q59UY7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q59UY7

No associated diseases with Q59UY7

2 regional properties for Q59UY7

Type Name Position InterPro Accession
domain Zn(2)Cys(6) fungal-type DNA-binding domain 84 - 131 IPR001138
domain Transcription factor domain, fungi 273 - 450 IPR007219

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Interaction with SFU1 promotes cytoplasmic localization whereas interaction with SSN3 and subsequent phosphorylation promotes nuclear localization
  • Nuclear localization is associated with virulence
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
transcription cis-regulatory region binding Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
zinc ion binding Binding to a zinc ion (Zn).

5 GO annotations of biological process

Name Definition
biological process involved in interaction with host An interaction between two organisms living together in more or less intimate association. The term host is used for the larger (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism.
cellular iron ion homeostasis Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell.
cellular response to alkaline pH Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH > 7. pH is a measure of the acidity or basicity of an aqueous solution.
filamentous growth The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.
regulation of DNA-templated transcription Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKFEKGKVRI LPKPSPTPTN PQTPLPLLPA QTKPVNSKRK SAASTPGNES KKSRKSNSTA
70 80 90 100 110 120
STPNSATPTS VGTPPQKTSK PTGHRPVTSC TFCRQHKIKC NASDNYPNPC ERCKKMGLKC
130 140 150 160 170 180
EIDPEFRPRK GSQIQSLKSD VDELKAKIEM LTKNESLLTQ ALNQHNLNHA SQQQQSSGSQ
190 200 210 220 230 240
SQQQHPPNPQ RALSYTSANS SPQVAFSNAS PIPSVTSIQQ NAPLTHENSD NSPYALNTPE
250 260 270 280 290 300
NIEELQPISE FILGDVTLPL NRANELHDKF MTTHLPFLPI IISRSATELY HKSQLLFWAV
310 320 330 340 350 360
ILTASLSEPE PKLYMSLASL IKQLAIETCW IKTPRSTHVI QALIILSIWP LPNEKVLDDC
370 380 390 400 410 420
SYRFVGLAKN LSLQLGLHRG GEFIQEFSRN QVSLGPDAER WRTRSWLAVF FCEQFWSSLL
430 440 450 460 470 480
GLPPSINTTD YLLENARVDK SLPKNFRCLI SLSIFQCKLV NIMGISVTRP DGLLEPSNRA
490 500 510 520 530 540
GSLSLLDREL ERLRFKLQFE EGGPIEVYYL YIKLMICCFA FLPGTPIEDQ VKYVSFAYLS
550 560 570 580 590 600
ATRIVTIVSK MVNDISLIEL PIYIRQAVTY SVFMLFKLHL SRYLIDKYVD SARQSIVTVH
610 620 630 640 650 660
RLFRNTLSSW KDLQNDISRT AKVLENLNMV LYNYPEIFLN DSENEDSSII TRMRSHLTAS
670 680 690 700 710 720
LFYDLVWCVH EARRRSVLDK GKRQAQPNKK ILPLPFYNQI TKDDFKTITT TSPNGTTITT
730 740 750 760 770 780
LVPTDQAMNQ AKSKSFDSSK PLEINGIPLP MLEATGSTRE VLDSLPSQSL PSQAPTLQQY
790 800 810 820 830 840
PMQQDQQQQE PSQQQQQKHS QQSQQYQQQQ QSNQQQPHLQ HQRQFQQSPP PQFSMISSTP
850 860 870 880 890 900
PLQQPPFILA NSPLPQTYLP KIDEMNMSPE VKQENSVAPF ASQITNFFDQ QTSGWFNNDN
910
QDDDFLGWFD VNMMQEK