Q59NX9
Gene name |
DPH5 (CAALFM_C503640WA, CaO19.6676) |
Protein name |
Diphthine methyl ester synthase 1 |
Names |
Diphthamide biosynthesis methyltransferase 1 |
Species |
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) |
KEGG Pathway |
cal:CAALFM_C503700CA |
EC number |
2.1.1.314: Methyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q59NX9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q59NX9-F1 | Predicted | AlphaFoldDB |
No variants for Q59NX9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q59NX9 | |||||
No associated diseases with Q59NX9
No regional properties for Q59NX9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q59NX9 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.1.1.314 | Methyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| diphthine synthase activity | Catalysis of the reaction: S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine = S-adenosyl-L-homocysteine + 2-(3-carboxy-3-(methylammonio)propyl)-L-histidine. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| methylation | The process in which a methyl group is covalently attached to a molecule. |
| peptidyl-diphthamide biosynthetic process from peptidyl-histidine | The modification of peptidyl-histidine to 2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine, known as diphthamide, found in translation elongation factor EF-2. The process occurs in eukaryotes and archaea but not eubacteria. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLYLIGLGLS | YESDITVRGL | ETVKKCKRVY | LEAYTSILMA | ANQESLEKFY | GREIILADRE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LVETGSDDIL | KDADKEDVAF | LVVGDPFGAT | THTDLVIRAR | ELGIKVETIH | NASVMNAVGA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| CGLQLYQFGQ | TVSLVFFTDS | WKPDSFYGKI | MENRKIGLHT | LLLLDIKVKE | QSIENMARGR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LIYEPPRYMD | IATAAQQLLE | IESIRQEQAY | TPNTPCVAIS | RLGSPTQTFK | AGTLQELSEY |
| 250 | 260 | 270 | 280 | 290 | |
| DSGEPLHSLV | MLGRQVHELE | LEYLYQFVDD | KEKFKKFVEQ | DQEFFKPAPY | VPPEDVDSE |