AiPD: Autoinhibited Protein Database

Gene name	parE
Protein name	DNA topoisomerase 4 subunit B
Names	Topoisomerase IV subunit B
Species	Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
KEGG Pathway	spn:SP_0852
EC number	5.6.2.2: Enzymes altering nucleic acid conformation
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

357-444 (Predicted disordered autoinhibitory region) PR

357-444 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
3FOE	X-ray	400 A	C/D	404-647	PDB
3FOF	X-ray	400 A	C/D	404-647	PDB
3K9F	X-ray	290 A	C/D	404-647	PDB
3KSA	X-ray	330 A	C/D	404-647	PDB
3KSB	X-ray	350 A	C/D	404-647	PDB
3LTN	X-ray	310 A	C/D	404-647	PDB
3RAD	X-ray	335 A	C/D	404-647	PDB
3RAE	X-ray	290 A	C/D	404-647	PDB
3RAF	X-ray	324 A	C/D	404-647	PDB
4I3H	X-ray	370 A	A/B	1-647	PDB
4JUO	X-ray	653 A	C	1-647	PDB
4KOE	X-ray	302 A	C/D	404-647	PDB
4KPE	X-ray	343 A	C/D	404-647	PDB
4KPF	X-ray	324 A	C/D	404-647	PDB
4Z3O	X-ray	344 A	A/B	404-643	PDB
4Z4Q	X-ray	304 A	A/B	404-643	PDB
4Z53	X-ray	326 A	A/B	404-643	PDB
5J5P	X-ray	197 A	A/B	1-402	PDB
5J5Q	X-ray	283 A	A/B/C/D	1-402	PDB
AF-Q59961-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
No variants for Q59961

Type	Name	Position	InterPro Accession
domain	DNA gyrase B subunit, C-terminal	573 - 634	IPR002288
domain	Histidine kinase/HSP90-like ATPase	36 - 182	IPR003594
domain	TOPRIM domain	427 - 541	IPR006171
domain	DNA topoisomerase, type IIA, subunit B, domain 2	227 - 397	IPR013506
conserved_site	DNA topoisomerase, type IIA, conserved site	431 - 439	IPR018522

		Description
EC Number	5.6.2.2	Enzymes altering nucleic acid conformation
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
chromosome	A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2.
metal ion binding	Binding to a metal ion.

Name	Definition
chromosome segregation	The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
DNA topological change	The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins