Q59749

PR
Gene name
parC
Protein name
DNA topoisomerase 4 subunit A
Names
Topoisomerase IV subunit A
Species
Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
KEGG Pathway
sme:SMc01761
EC number
5.6.2.2: Enzymes altering nucleic acid conformation
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-43 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q59749

Entry ID Method Resolution Chain Position Source
AF-Q59749-F1 Predicted AlphaFoldDB

No variants for Q59749

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q59749

No associated diseases with Q59749

4 regional properties for Q59749

Type Name Position InterPro Accession
domain DNA topoisomerase, type IIA, domain A 18 - 479 IPR002205
repeat DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat 567 - 613 IPR006691-1
repeat DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat 620 - 659 IPR006691-2
repeat DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat 665 - 702 IPR006691-3

Functions

Description
EC Number 5.6.2.2 Enzymes altering nucleic acid conformation
Subcellular Localization
  • Cell membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
extrinsic component of plasma membrane The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2.

2 GO annotations of biological process

Name Definition
chromosome segregation The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
DNA topological change The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGQSLLPPSG GDDNIQPVDL KAALEERYLA YALSTIMHRA LPDVRDGLKP VHRRIIHAMS
70 80 90 100 110 120
EMGLRPNSSF KKCARIVGDV IGKFHPHGDQ SVYDALVRLA QDFSQRYPVV DGQGNFGNID
130 140 150 160 170 180
GDNAAAYRYT EAKMTEVAAL LLEGIDQDAV DFRPTYNEED QEPTVLPGAF PNLLANGASG
190 200 210 220 230 240
IAVGMATSIP PHNAHELCDA ALHLIKHPDA TVEDLLFDPA NPQRGGIEGP DFPTGGVIVE
250 260 270 280 290 300
SRASMAESYR TGRGGFRVRA RWAVEDLGRG GFQIVVTEIP YQVQKSRLIE KIAELLIARK
310 320 330 340 350 360
LPLLEDIRDE SAEDVRVVLV PKSRSVDANI LMESLFKLTE LESRIPLNMN VLSMGRVPRV
370 380 390 400 410 420
MALNEVLSEW LAHRREVLQR RSRHRLAAID RRLEILGGYL IAYLNIDEVI RIIREEDEPK
430 440 450 460 470 480
AVMIERFGLT DVQAEAILNM RLRSLRKLEE FEIRTEFDSL SKEKAEIEAL LASGDKQWQA
490 500 510 520 530 540
VAWEIGEVKK KFAKATELGK RRSTFSDAPD ADVEAIQQAM IEKEPITVVI SEKGWIRALK
550 560 570 580 590 600
GHIADTSSLQ FKDGDGLKVS FPAQTTDKIL IFTTGGKAYT LGGDKLPGGR GHGEPLRIMV
610 620 630 640 650 660
DMENDQDVLT AFVHDPARKL IVSSTAGNGF VVTESDIVAN TRKGKQVMNV TMPDEAKLVV
670 680 690 700 710 720
PVKGDHLAVV GENRKMLVFP LVQVPEMARG KGVRLQRYKD GGVSDIRSFA IAEGLTWEDS
730 740 750
AGRVFTKTRD ELIEWMGDRA GAGRVVPKGF PRSGKFSG